Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls

Abbas Parsian, C. Robert Cloninger, Zhen Hua Zhang

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    30 Scopus citations

    Abstract

    To determine the role of CYP2E1 gene in susceptibility to alcoholism and alcohol cirrhosis, we genotyped a sample of alcoholics with and without cirrhosis, alcoholics with antisocial personality, alcoholic families, and normal controls with Rsal, Pstl, and Dral polymorphisms in the gene. Relative risk and haplotype relative risk approaches were used in genotype data analysis. The Pstl polymorphism data were excluded from further analysis due to strong linkage disequilibrium with Rsal. For the Rsal polymorphism, comparison of total alcoholics, alcoholics with and without cirrhosis, and alcoholics with antisocial personality with normal controls were negative. The results of the same analysis with the above groups for Dral were also negative. Using the haplotype relative risk method, the result for Dral was positive, meaning that the mutated allele (D2) was significantly more transmitted than nontransmitted. However, the result of the same analysis for the Rsal polymorphism was not statistically significant. We conclude that the CYP2E1 gene plays no substantial role in susceptibility to alcohol cirrhosis or alcoholism.

    Original languageEnglish
    Pages (from-to)888-891
    Number of pages4
    JournalAlcoholism: Clinical and Experimental Research
    Volume22
    Issue number4
    DOIs
    StatePublished - 1998

    Keywords

    • Cirrhosis
    • Cytochrome CYP2E1
    • Haplotype Relative Risk
    • Polymorphism
    • Relative Risk

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