Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture

Eric J. Lenze; Michael C. Munin; Robert E. Ferrell; Bruce G. Pollock; Elizabeth Skidmore; Francis Lotrich; Joan C. Rogers; Tanya Quear; Patricia Houck; Charles F. Reynolds

doi:10.1097/00019442-200505000-00014

Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture

Eric J. Lenze, Michael C. Munin, Robert E. Ferrell, Bruce G. Pollock, Elizabeth Skidmore, Francis Lotrich, Joan C. Rogers, Tanya Quear, Patricia Houck, Charles F. Reynolds

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Abstract

Objective: The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event. Methods: This was a prospective, observational study of 23 elderly rehabilitation-hospital patients during their inpatient stay. Depressive symptoms were assessed by Hamilton Rating Scale for Depression (Ham-D) and PRIME-MD. Subjects were also genotyped for 5-HTTLPR. Results: Survival analysis showed that genotype significantly predicted time-to-major depressive episode. Subjects with an s allele (genotype s/l or s/s) had significantly higher Ham-D scores over 14 weeks of follow-up than those with the l/l genotype. Conclusion: Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. This finding requires confirmation in a larger sample.

Original language	English
Pages (from-to)	428-432
Number of pages	5
Journal	American Journal of Geriatric Psychiatry
Volume	13
Issue number	5
DOIs	https://doi.org/10.1097/00019442-200505000-00014
State	Published - May 2005

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Lenze, E. J., Munin, M. C., Ferrell, R. E., Pollock, B. G., Skidmore, E., Lotrich, F., Rogers, J. C., Quear, T., Houck, P., & Reynolds, C. F. (2005). Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. American Journal of Geriatric Psychiatry, 13(5), 428-432. https://doi.org/10.1097/00019442-200505000-00014

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title = "Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture",

abstract = "Objective: The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event. Methods: This was a prospective, observational study of 23 elderly rehabilitation-hospital patients during their inpatient stay. Depressive symptoms were assessed by Hamilton Rating Scale for Depression (Ham-D) and PRIME-MD. Subjects were also genotyped for 5-HTTLPR. Results: Survival analysis showed that genotype significantly predicted time-to-major depressive episode. Subjects with an s allele (genotype s/l or s/s) had significantly higher Ham-D scores over 14 weeks of follow-up than those with the l/l genotype. Conclusion: Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. This finding requires confirmation in a larger sample.",

author = "Lenze, {Eric J.} and Munin, {Michael C.} and Ferrell, {Robert E.} and Pollock, {Bruce G.} and Elizabeth Skidmore and Francis Lotrich and Rogers, {Joan C.} and Tanya Quear and Patricia Houck and Reynolds, {Charles F.}",

note = "Funding Information: This research was supported by National Institute of Mental Health grants K23 MH64196 and P30 MH52247 . ",

year = "2005",

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doi = "10.1097/00019442-200505000-00014",

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Lenze, EJ, Munin, MC, Ferrell, RE, Pollock, BG, Skidmore, E, Lotrich, F, Rogers, JC, Quear, T, Houck, P & Reynolds, CF 2005, 'Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture', American Journal of Geriatric Psychiatry, vol. 13, no. 5, pp. 428-432. https://doi.org/10.1097/00019442-200505000-00014

TY - JOUR

T1 - Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture

AU - Lenze, Eric J.

AU - Munin, Michael C.

AU - Ferrell, Robert E.

AU - Pollock, Bruce G.

AU - Skidmore, Elizabeth

AU - Lotrich, Francis

AU - Rogers, Joan C.

AU - Quear, Tanya

AU - Houck, Patricia

AU - Reynolds, Charles F.

N1 - Funding Information: This research was supported by National Institute of Mental Health grants K23 MH64196 and P30 MH52247 .

PY - 2005/5

Y1 - 2005/5

N2 - Objective: The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event. Methods: This was a prospective, observational study of 23 elderly rehabilitation-hospital patients during their inpatient stay. Depressive symptoms were assessed by Hamilton Rating Scale for Depression (Ham-D) and PRIME-MD. Subjects were also genotyped for 5-HTTLPR. Results: Survival analysis showed that genotype significantly predicted time-to-major depressive episode. Subjects with an s allele (genotype s/l or s/s) had significantly higher Ham-D scores over 14 weeks of follow-up than those with the l/l genotype. Conclusion: Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. This finding requires confirmation in a larger sample.

AB - Objective: The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event. Methods: This was a prospective, observational study of 23 elderly rehabilitation-hospital patients during their inpatient stay. Depressive symptoms were assessed by Hamilton Rating Scale for Depression (Ham-D) and PRIME-MD. Subjects were also genotyped for 5-HTTLPR. Results: Survival analysis showed that genotype significantly predicted time-to-major depressive episode. Subjects with an s allele (genotype s/l or s/s) had significantly higher Ham-D scores over 14 weeks of follow-up than those with the l/l genotype. Conclusion: Depressive symptoms and major depressive disorder in elderly persons after a stressful medical event may be associated with 5-HTTLPR genotype. This finding requires confirmation in a larger sample.

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Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture

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