TY - JOUR
T1 - Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients
AU - Stewart, Kelly L.
AU - Gigic, Biljana
AU - Himbert, Caroline
AU - Warby, Christy A.
AU - Ose, Jennifer
AU - Lin, Tengda
AU - Schrotz-King, Petra
AU - Boehm, Jürgen
AU - Jordan, Kristine C.
AU - Metos, Julie
AU - Schneider, Martin
AU - Figueiredo, Jane C.
AU - Li, Christopher I.
AU - Shibata, David
AU - Siegel, Erin
AU - Toriola, Adetunji T.
AU - Hardikar, Sheetal
AU - Ulrich, Cornelia M.
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-surgery serum samples were obtained from 191 patients diagnosed with primary invasive stage I-IV CRC. Biomarkers of inflammation (CRP, SAA, IL-6, IL-8, MCP-1, TNFα) and angiogenesis (VEGFA, VEGFD, sICAM-1 and sVCAM-1) were analyzed (Meso-Scale-Discovery). Fructose, glucose, sucrose, and total sugar intake (calories/day, % total calories) were assessed by FFQ. Pearson’s correlation and multiple linear regression analyses were performed. Patients were on average 64 years old, 64% were male, the majority was diagnosed with stage II-III (58%) cancers, and 67% were either overweight or obese. Among normal-weight individuals (BMI <25 kg/m2), we observed a significant inverse association between VEGFD and any type of sugar intake in cal/day (sucrose: p = 0.01, glucose and fructose: p < 0.001) and MCP-1 and fructose intake (p = 0.05). The magnitude of reduction in VEGF ranged between −1.24 for sucrose to 4.49 for glucose intake, and −2.64 for fructose intake for MCP-1 levels. Sugar intake was associated with some inflammation or angiogenesis biomarkers, among CRC patients; differences were observed by adiposity that warrant further investigation. Supplemental data for this article is available online at at 10.1080/01635581.2021.1957133.
AB - Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-surgery serum samples were obtained from 191 patients diagnosed with primary invasive stage I-IV CRC. Biomarkers of inflammation (CRP, SAA, IL-6, IL-8, MCP-1, TNFα) and angiogenesis (VEGFA, VEGFD, sICAM-1 and sVCAM-1) were analyzed (Meso-Scale-Discovery). Fructose, glucose, sucrose, and total sugar intake (calories/day, % total calories) were assessed by FFQ. Pearson’s correlation and multiple linear regression analyses were performed. Patients were on average 64 years old, 64% were male, the majority was diagnosed with stage II-III (58%) cancers, and 67% were either overweight or obese. Among normal-weight individuals (BMI <25 kg/m2), we observed a significant inverse association between VEGFD and any type of sugar intake in cal/day (sucrose: p = 0.01, glucose and fructose: p < 0.001) and MCP-1 and fructose intake (p = 0.05). The magnitude of reduction in VEGF ranged between −1.24 for sucrose to 4.49 for glucose intake, and −2.64 for fructose intake for MCP-1 levels. Sugar intake was associated with some inflammation or angiogenesis biomarkers, among CRC patients; differences were observed by adiposity that warrant further investigation. Supplemental data for this article is available online at at 10.1080/01635581.2021.1957133.
UR - http://www.scopus.com/inward/record.url?scp=85112037057&partnerID=8YFLogxK
U2 - 10.1080/01635581.2021.1957133
DO - 10.1080/01635581.2021.1957133
M3 - Article
C2 - 34369225
AN - SCOPUS:85112037057
SN - 0163-5581
VL - 74
SP - 1636
EP - 1643
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 5
ER -