Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy

Adetunji T. Toriola; Helja Marja Surcel; Anika Husing; Kjell Grankvist; Hans Ake Lakso; Helena Schock; Eva Lundin; Matti Lehtinen; Annekatrin Lukanova

doi:10.1007/s10552-011-9752-5

Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy

Adetunji T. Toriola
, Helja Marja Surcel
, Anika Husing
, Kjell Grankvist
, Hans Ake Lakso
, Helena Schock
, Eva Lundin
, Matti Lehtinen
, Annekatrin Lukanova

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

Original language	English
Pages (from-to)	925-928
Number of pages	4
Journal	Cancer Causes and Control
Volume	22
Issue number	6
DOIs	https://doi.org/10.1007/s10552-011-9752-5
State	Published - Jun 2011

Keywords

Androstenedione
Estradiol
IGF-1
Pregnancy
Progesterone
Sex steroids
Testosterone
Vitamin D

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10.1007/s10552-011-9752-5

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@article{1152c308b5c1446f9c737075274d405e,

title = "Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy",

abstract = "Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6\% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.",

keywords = "Androstenedione, Estradiol, IGF-1, Pregnancy, Progesterone, Sex steroids, Testosterone, Vitamin D",

author = "Toriola, \{Adetunji T.\} and Surcel, \{Helja Marja\} and Anika Husing and Kjell Grankvist and Lakso, \{Hans Ake\} and Helena Schock and Eva Lundin and Matti Lehtinen and Annekatrin Lukanova",

note = "Funding Information: Acknowledgments Supported by grant number CA120061 from the US National Cancer Institute. Adetunji T Toriola was supported by an EACR (European Association for Cancer Research) Travel Fellowship Award to visit the Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg.",

year = "2011",

month = jun,

doi = "10.1007/s10552-011-9752-5",

language = "English",

volume = "22",

pages = "925--928",

journal = "Cancer Causes and Control",

issn = "0957-5243",

number = "6",

}

TY - JOUR

T1 - Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy

AU - Toriola, Adetunji T.

AU - Surcel, Helja Marja

AU - Husing, Anika

AU - Grankvist, Kjell

AU - Lakso, Hans Ake

AU - Schock, Helena

AU - Lundin, Eva

AU - Lehtinen, Matti

AU - Lukanova, Annekatrin

N1 - Funding Information: Acknowledgments Supported by grant number CA120061 from the US National Cancer Institute. Adetunji T Toriola was supported by an EACR (European Association for Cancer Research) Travel Fellowship Award to visit the Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg.

PY - 2011/6

Y1 - 2011/6

N2 - Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

AB - Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

KW - Androstenedione

KW - Estradiol

KW - IGF-1

KW - Pregnancy

KW - Progesterone

KW - Sex steroids

KW - Testosterone

KW - Vitamin D

UR - https://www.scopus.com/pages/publications/79956286965

U2 - 10.1007/s10552-011-9752-5

DO - 10.1007/s10552-011-9752-5

M3 - Article

C2 - 21387179

AN - SCOPUS:79956286965

SN - 0957-5243

VL - 22

SP - 925

EP - 928

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 6

ER -

Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy

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