TY - JOUR
T1 - Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy
AU - Toriola, Adetunji T.
AU - Surcel, Helja Marja
AU - Husing, Anika
AU - Grankvist, Kjell
AU - Lakso, Hans Ake
AU - Schock, Helena
AU - Lundin, Eva
AU - Lehtinen, Matti
AU - Lukanova, Annekatrin
N1 - Funding Information:
Acknowledgments Supported by grant number CA120061 from the US National Cancer Institute. Adetunji T Toriola was supported by an EACR (European Association for Cancer Research) Travel Fellowship Award to visit the Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg.
PY - 2011/6
Y1 - 2011/6
N2 - Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.
AB - Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.
KW - Androstenedione
KW - Estradiol
KW - IGF-1
KW - Pregnancy
KW - Progesterone
KW - Sex steroids
KW - Testosterone
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=79956286965&partnerID=8YFLogxK
U2 - 10.1007/s10552-011-9752-5
DO - 10.1007/s10552-011-9752-5
M3 - Article
C2 - 21387179
AN - SCOPUS:79956286965
SN - 0957-5243
VL - 22
SP - 925
EP - 928
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 6
ER -