Association of granulomas in mesenteric lymph nodes in Crohn's disease with younger age and transmural inflammation

Xingwen Sun, Lisi Yuan, Yi Li, Bo Shen, Hao Xie, Xiuli Liu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background and Aims: Mesenteric lymph nodes were usually removed during bowel resection surgery for Crohn's disease (CD). Mesenteric lymph node (MLN) granuloma predicted postoperative disease recurrence in patients with CD after ileocolic resection (ICR). This study was aimed to identify factors associated with MLN granulomas in a cohort of CD patients who underwent ICR. Methods: The study group consisted of 18 patients with CD who underwent the index ICR between 2004 and 2012 and had MLN granulomas. The control group included 32 cases negative for MLN granulomas, which were randomly selected from the same period. Clinicodemographic and histological features were compared in these two groups. Results: The presence of MLN granuloma was associated with younger age, perianal disease, and ileocolic disease. Gender, body mass index, smoking status, disease duration, extraintestinal manifestation, length of bowel resected, total number of nodes examined, medical treatment, and indications for surgery were not significantly different between the groups. The presence of MLN granuloma was associated with mural granuloma, transmural inflammation, mural abscess, hypertrophy of the muscularis propria, fibrosis of the muscularis propria, and serosal fibrosis in the small bowel. The multivariable analysis confirms that MLN granuloma was associated with age and transmural inflammation. Conclusions: In CD patients who underwent the index ICR, the presence of MLN granuloma was associated with younger age and transmural inflammation. Our current results suggest that the detection of MLN granulomas may be enhanced in patients at higher risk, that is, younger patients or those with transmural inflammation on imaging or histopathology.

Original languageEnglish
Pages (from-to)1463-1468
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume32
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • Crohn's disease
  • fibrosis
  • granuloma
  • ileocolic resection
  • mesenteric lymph node
  • transmural inflammation

Fingerprint

Dive into the research topics of 'Association of granulomas in mesenteric lymph nodes in Crohn's disease with younger age and transmural inflammation'. Together they form a unique fingerprint.

Cite this