Association of genetic variants in the apelin-APJ system and ace2 with blood pressure responses to potassium supplementation: The gensalt study

Qi Zhao, Dongfeng Gu, Tanika N. Kelly, James E. Hixson, Dabeeru C. Rao, Cashell E. Jaquish, Jing Chen, Jianfeng Huang, Chung Shiuan Chen, C. Charles Gu, Paul K. Whelton, Jiang He

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34 Scopus citations

Abstract

Background: Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. Methods: We conducted a 7-day potassium supplementation (60mmol/day) intervention among 1,906 Chinese adults who participated in the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. Tag single-nucleotide polymorphisms (SNPs) based on HapMap data and potential functional SNPs were selected in the APLN, APLNR, and ACE2 genes. Because the ACE2 and APLN genes are located on the X chromosome, men and women were analyzed separately. Results: In women, SNP rs2235306 in the APLN gene was significantly associated with diastolic BP (DBP) response to potassium supplementation (P = 0.0009). The DBP responses (95% confidence interval (CI)) among those with genotypes T/T, T/C, and C/C were-2.22 (-2.74,-1.70),-1.69 (-2.20,-1.19), and-0.81 (-1.54,-0.09) mmHg, respectively. In men, SNP rs4646174 of the ACE2 gene was significantly associated with systolic BP (SBP), DBP, and mean arterial pressure (MAP) responses to potassium supplementation (P = 0.0001, P = 0.001, and P = 3.0 × 10-6, respectively). The SBP, DBP, and MAP responses (95% CI) were-0.79 (-2.27, 0.69) vs.-3.53 (-3.94,-3.12), 1.07 (-0.34, 2.49) vs.-1.06 (-1.43,-0.69), and 0.44 (-0.60, 1.48) vs.-1.89 (-2.22,-1.55) mmHg among men with minor G allele compared to those with major C allele of rs4646174, respectively. Conclusion Our study indicates that genetic variation of APLN and ACE2 may influence BP response to potassium intake.

Original languageEnglish
Pages (from-to)606-613
Number of pages8
JournalAmerican Journal of Hypertension
Volume23
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • ACE2
  • Apelin
  • Apelin receptor
  • Blood pressure
  • Hypertension
  • Polymorphism
  • Potassium supplement

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