TY - JOUR
T1 - Association of depression witk reduced heart rate variability in coronary artery disease
AU - Carney, Robert M.
AU - Saunders, Roger D.
AU - Freedland, Kenneth E.
AU - Stein, Phyllis
AU - Rich, Michael W.
AU - Jaffe, Allan S.
N1 - Funding Information:
From the Departments of Psychiatry and Medicine, Washington University School of Medicine, St. Louis, Missouri. This study was sup ported by Grant ROl Ht42427-03 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Manuscript received March 27, 1995; revised manuscript received and accepted June 2 1, 1995. Address for reprints: Robert M. Carney, PhD, Department of Psy chiatry, Washington University School of Medicine, 216 South Kings-highway, St. Louis, Missouri 63 1 10.
PY - 1995/9/15
Y1 - 1995/9/15
N2 - Decreased heart rate (HR) variability is an independent risk factor for mortality in cardiac populations. Clinical depression has also been associated with adverse outcomes in patients with coronary artery disease (CAD). This study tests the hypothesis that depressed patients with CAD have decreased HR variability compared with nondepressed CAD patients. Nineteen patients with angiographically documented CAD and either major or minor depression were compared with a sample of nondepressed CAD patients according to age, sex, and smoking status. All patients underwent 24-hour Holter monitoring, and the standard deviation of all normal-to-normal intervals was used as the primary index of HR variability. HR variability was significantly lower in depressed than nondepressed patients (90 ± 35 vs 117 ± 26 ms; p < 0.01), even after adjusting for relevant covariates. Thus, decreased HR variability may help explain the increased risk for cardiac mortality and morbidity in depressed CAD patients.
AB - Decreased heart rate (HR) variability is an independent risk factor for mortality in cardiac populations. Clinical depression has also been associated with adverse outcomes in patients with coronary artery disease (CAD). This study tests the hypothesis that depressed patients with CAD have decreased HR variability compared with nondepressed CAD patients. Nineteen patients with angiographically documented CAD and either major or minor depression were compared with a sample of nondepressed CAD patients according to age, sex, and smoking status. All patients underwent 24-hour Holter monitoring, and the standard deviation of all normal-to-normal intervals was used as the primary index of HR variability. HR variability was significantly lower in depressed than nondepressed patients (90 ± 35 vs 117 ± 26 ms; p < 0.01), even after adjusting for relevant covariates. Thus, decreased HR variability may help explain the increased risk for cardiac mortality and morbidity in depressed CAD patients.
UR - http://www.scopus.com/inward/record.url?scp=0029088722&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(99)80155-6
DO - 10.1016/S0002-9149(99)80155-6
M3 - Article
C2 - 7677077
AN - SCOPUS:0029088722
SN - 0002-9149
VL - 76
SP - 562
EP - 564
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 8
ER -