Association of Depression and Cognitive Dysfunction with Patient-Centered Outcomes after Transcatheter Aortic Valve Replacement

Bassim El-Sabawi, Harrison Cloud, Jay N. Patel, Susan P. Bell, Sammy Elmariah, William F. Fearon, Juyong B. Kim, Robert N. Piana, Samir R. Kapadia, Dharam J. Kumbhani, Linda D. Gillam, Brian K. Whisenant, Nishath Quader, Alan Zajarias, Frederick G. Welt, Anthony A. Bavry, Megan Coylewright, Anna Vatterott, Natalie Jackson, Shi HuangBrian R. Lindman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


BACKGROUND: Depression and cognitive dysfunction (CD) are not routinely screened for in patients before transcatheter aortic valve replacement (TAVR) and their association with postprocedural outcomes is poorly understood. The objectives of this study are to determine the prevalence of depression and CD in patients with aortic stenosis undergoing TAVR and evaluate their association with mortality and quality of life. METHODS: We analyzed a prospective, multicenter TAVR registry that systematically screened patients for preexisting depression and CD with the Patient Health Questionnaire-2 and Mini-Cog, respectively. The associations with mortality were assessed with Cox proportional hazard models and quality of life (Kansas City Cardiomyopathy Questionnaire and EuroQol visual analogue scale) were evaluated using multivariable ordinal regression models. RESULTS: A total of 884 patients were included; median follow-up was 2.88 years (interquartile range=1.2-3.7). At baseline, depression was observed in 19.6% and CD in 31.8%. In separate models, after adjustment, depression (HR, 1.45 [95% CI, 1.13-1.86]; P<0.01) and CD (HR, 1.27 [95% CI, 1.02-1.59]; P=0.04) were each associated with increased mortality. Combining depression and CD into a single model, mortality was greatest among those with both depression and CD (n=62; HR, 2.06 [CI, 1.44-2.96]; P<0.01). After adjustment, depression was associated with 6.6 (0.3-13.6) points lower on the Kansas City Cardiomyopathy Questionnaire 1-year post-TAVR and 6.7 (0.5-12.7) points lower on the EuroQol visual analogue scale. CD was only associated with lower EuroQol visual analogue scale. CONCLUSIONS: Depression and CD are common in patients that undergo TAVR and are associated with increased mortality and worse quality of life. Depression may be a modifiable therapeutic target to improve outcomes after TAVR.

Original languageEnglish
Pages (from-to)E012875
JournalCirculation: Cardiovascular Interventions
Issue number8
StatePublished - Aug 1 2023


  • aortic valve stenosis
  • depression
  • mortality
  • quality of life
  • transcatheter aortic valve replacement


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