Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy

M. A. Brantley, S. L. Edelstein, J. M. King, M. R. Plotzke, R. S. Apte, S. M. Kymes, A. Shiels

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Aim: To determine whether there is an association between complement factor H (CFH) or LOC387715 genotypes and response to treatment with photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD). Methods: Sixty-nine patients being treated for neovascular AMD with PDT were genotyped for the CFH Y402H and LOC387715 A69S polymorphisms by allele-specific digestion of PCR products. AMD phenotypes were characterized by clinical examination, fundus photography, and fluorescein angiography. Results: Adjusting for age, pre-PDT visual acuity (VA), and lesion type, mean VA after PDT was significantly worse for the CFH TT genotype than for the TC or CC genotypes (P=0.05). Post-PDT VA was significantly worse for the CFH TT genotype in the subgroup of patients with predominantly classic choroidal neovascular lesions (P=0.04), but not for the patients with occult lesions (P=0.22). For the LOC387715 A69S variant, there was no significant difference among the genotypes in response to PDT therapy. Conclusions: The CFH Y402H variant was associated with a response to PDT treatment in this study. Patients with the CFH TT genotype fared significantly worse with PDT than did those with the CFH TC and CC genotypes, suggesting a potential relationship between CFH genotype and response to PDT.

Original languageEnglish
Pages (from-to)626-631
Number of pages6
JournalEye
Volume23
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • AMD
  • CFH
  • LOC387715
  • Photodynamic

Fingerprint

Dive into the research topics of 'Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy'. Together they form a unique fingerprint.

Cite this