Association between resistance to vancomycin and death in cases of Enterococcus faecium bacteremia

Jane M. Garbutt, Madhuri Ventrapragada, Benjamin Littenberg, Linda M. Mundy

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

We conducted a retrospective cohort study to determine the association between resistance to vancomycin and mortality among hospitalized patients with Enterococcus faecium bacteremia. We compared outcomes for patients infected with vancomycin-resistant versus vancomycin-susceptible E. faecium among 69 patients with bacteremia defined according to the National Nosocomial Infections Surveillance system. The univariate odds ratio (OR) for death associated with vancomycin resistance was 2.1 (P = .172). After controlling for severity of illness, we found that vancomycin resistance was not associated with mortality (OR, 1.74; 95% confidence interval, 0.5-6.12; P = .39). Vancomycin resistance does not independently increase mortality among patients with E. faecium bacteremia.

Original languageEnglish
Pages (from-to)466-472
Number of pages7
JournalClinical Infectious Diseases
Volume30
Issue number3
DOIs
StatePublished - Apr 26 2000

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