TY - JOUR
T1 - Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor
AU - Liu, Li
AU - Nishihara, Reiko
AU - Qian, Zhi Rong
AU - Tabung, Fred K.
AU - Nevo, Daniel
AU - Zhang, Xuehong
AU - Song, Mingyang
AU - Cao, Yin
AU - Mima, Kosuke
AU - Masugi, Yohei
AU - Shi, Yan
AU - da Silva, Annacarolina
AU - Twombly, Tyler
AU - Gu, Mancang
AU - Li, Wanwan
AU - Hamada, Tsuyoshi
AU - Kosumi, Keisuke
AU - Inamura, Kentaro
AU - Nowak, Jonathan A.
AU - Drew, David A.
AU - Lochhead, Paul
AU - Nosho, Katsuhiko
AU - Wu, Kana
AU - Wang, Molin
AU - Garrett, Wendy S.
AU - Chan, Andrew T.
AU - Fuchs, Charles S.
AU - Giovannucci, Edward L.
AU - Ogino, Shuji
N1 - Publisher Copyright:
© 2017 AGA Institute
PY - 2017/12
Y1 - 2017/12
N2 - Background & Aims Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions. Methods We collected data from the molecular pathological epidemiology databases of 2 prospective cohort studies: the Nurses’ Health Study (since 1976) and the Health Professionals Follow-Up Study (since 1986). We used duplication-method time-varying Cox proportional cause-specific hazards regression to assess the association of empirical dietary inflammatory pattern (EDIP) score (derived from food frequency questionnaire data) with colorectal carcinoma subtype. Foods that contribute to high EDIP scores include red and processed meats, refined grains, carbonated beverages, and some vegetables; foods that contribute to low EDIP scores include beer, wine, coffee, tea, yellow and leafy vegetables, and fruit juice. Colorectal tissue samples were analyzed histologically for patterns of lymphocytic reactions (Crohn's-like lymphoid reaction, peritumoral lymphocytic reaction, intratumoral periglandular reaction, and tumor-infiltrating lymphocytes). Results During follow-up of 124,433 participants, we documented 1311 incident colon and rectal cancer cases with available tissue data. The association between the EDIP and colorectal cancer risk was significant (Ptrend =.02), and varied with degree of peritumoral lymphocytic reaction (Pheterogeneity <.001). Higher EDIP scores were associated with increased risk of colorectal cancer with an absent or low peritumoral lymphocytic reaction (highest vs lowest EDIP score quintile hazard ratio, 2.60; 95% confidence interval, 1.60−4.23; Ptrend <.001), but not risk of tumors with intermediate or high peritumoral lymphocytic reaction (Ptrend >.80). Conclusions In 2 prospective cohort studies, we associated inflammatory diets with a higher risk of colorectal cancer subtype that contains little or no peritumoral lymphocytic reaction. These findings suggest that diet-related inflammation might contribute to development of colorectal cancer, by suppressing the adaptive anti-tumor immune response.
AB - Background & Aims Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions. Methods We collected data from the molecular pathological epidemiology databases of 2 prospective cohort studies: the Nurses’ Health Study (since 1976) and the Health Professionals Follow-Up Study (since 1986). We used duplication-method time-varying Cox proportional cause-specific hazards regression to assess the association of empirical dietary inflammatory pattern (EDIP) score (derived from food frequency questionnaire data) with colorectal carcinoma subtype. Foods that contribute to high EDIP scores include red and processed meats, refined grains, carbonated beverages, and some vegetables; foods that contribute to low EDIP scores include beer, wine, coffee, tea, yellow and leafy vegetables, and fruit juice. Colorectal tissue samples were analyzed histologically for patterns of lymphocytic reactions (Crohn's-like lymphoid reaction, peritumoral lymphocytic reaction, intratumoral periglandular reaction, and tumor-infiltrating lymphocytes). Results During follow-up of 124,433 participants, we documented 1311 incident colon and rectal cancer cases with available tissue data. The association between the EDIP and colorectal cancer risk was significant (Ptrend =.02), and varied with degree of peritumoral lymphocytic reaction (Pheterogeneity <.001). Higher EDIP scores were associated with increased risk of colorectal cancer with an absent or low peritumoral lymphocytic reaction (highest vs lowest EDIP score quintile hazard ratio, 2.60; 95% confidence interval, 1.60−4.23; Ptrend <.001), but not risk of tumors with intermediate or high peritumoral lymphocytic reaction (Ptrend >.80). Conclusions In 2 prospective cohort studies, we associated inflammatory diets with a higher risk of colorectal cancer subtype that contains little or no peritumoral lymphocytic reaction. These findings suggest that diet-related inflammation might contribute to development of colorectal cancer, by suppressing the adaptive anti-tumor immune response.
KW - Adaptive Immune Cells
KW - BRAF
KW - CpG Island Methylator Phenotype
KW - Cyclooxygenase-2
UR - http://www.scopus.com/inward/record.url?scp=85032941903&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2017.08.045
DO - 10.1053/j.gastro.2017.08.045
M3 - Article
C2 - 28865736
AN - SCOPUS:85032941903
SN - 0016-5085
VL - 153
SP - 1517-1530.e14
JO - Gastroenterology
JF - Gastroenterology
IS - 6
ER -