Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy

Ezequiel Gleichgerrcht, Daniel L. Drane, Simon S. Keller, Kathryn A. Davis, Robert Gross, Jon T. Willie, Nigel Pedersen, Christophe de Bezenac, Jens Jensen, Ruben Kuzniecky, Leonardo Bonilha

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background and Objectives To determine the association between surgical lesions of distinct gray and white structures and connections with favorable postoperative seizure outcomes. Methods Patients with drug-resistant temporal lobe epilepsy (TLE) from 3 epilepsy centers were included. We employed a voxel-based and connectome-based mapping approach to determine the association between favorable outcomes and surgery-induced temporal lesions. Analyses were conducted controlling for multiple confounders, including total surgical resection/ablation volume, hippocampal volumes, side of surgery, and site where the patient was treated. Results The cohort included 113 patients with TLE (54 women; 86 right-handed; mean age at seizure onset 16.5 years [SD 11.9]; 54.9% left) who were 61.1% free of disabling seizures (Engel Class 1) at follow-up. Postoperative seizure freedom in TLE was associated with (1) surgical lesions that targeted the hippocampus as well as the amygdala–piriform cortex complex and entorhinal cortices; (2) disconnection of temporal, frontal, and limbic regions through loss of white matter tracts within the uncinate fasciculus, anterior commissure, and fornix; and (3) functional disconnection of the frontal (superior and middle frontal gyri, orbitofrontal region) and temporal (superior and middle pole) lobes. Discussion Better postoperative seizure freedom is associated with surgical lesions of specific structures and connections throughout the temporal lobes. These findings shed light on the key components of epileptogenic networks in TLE and constitute a promising source of new evidence for future improvements in surgical interventions.

Original languageEnglish
Pages (from-to)E141-E151
JournalNeurology
Volume98
Issue number2
DOIs
StatePublished - Jan 11 2022

Fingerprint

Dive into the research topics of 'Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy'. Together they form a unique fingerprint.

Cite this