TY - JOUR
T1 - Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
AU - Dick, Danielle M.
AU - Plunkett, Jevon
AU - Hamlin, Damara
AU - Nurnberger, John
AU - Kuperman, Sam
AU - Schuckit, Marc
AU - Hesselbrock, Victor
AU - Edenberg, Howard
AU - Bierut, Laura
PY - 2007/2
Y1 - 2007/2
N2 - The objective of this study was to analyze association of the serotonin transporter gene 5-HTTLPR polymorphism on lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. We conducted family-based association analyses in 1913 Caucasians genotyped for the 5-HTTLPR polymorphism. We found evidence for association of the short allele with depression, but no evidence of association with alcohol dependence. On the basis of the evidence that the effect of this polymorphism may be moderated by stressful life events, we classified individuals for the presence and/or absence of stress, as defined by unemployment, relationship problems, or poor health. The evidence for the association with lifetime depression was limited to the group of individuals who had experienced stress, paralleling the direction of effects originally reported by Caspi and colleagues. No evidence was found for the association with alcohol dependence in either the stress or the no-stress groups.
AB - The objective of this study was to analyze association of the serotonin transporter gene 5-HTTLPR polymorphism on lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. We conducted family-based association analyses in 1913 Caucasians genotyped for the 5-HTTLPR polymorphism. We found evidence for association of the short allele with depression, but no evidence of association with alcohol dependence. On the basis of the evidence that the effect of this polymorphism may be moderated by stressful life events, we classified individuals for the presence and/or absence of stress, as defined by unemployment, relationship problems, or poor health. The evidence for the association with lifetime depression was limited to the group of individuals who had experienced stress, paralleling the direction of effects originally reported by Caspi and colleagues. No evidence was found for the association with alcohol dependence in either the stress or the no-stress groups.
KW - Association analyses
KW - Gene-environment interaction
KW - Lifetime depression
KW - Serotonin transporter
KW - Stressful life events
UR - http://www.scopus.com/inward/record.url?scp=33845643979&partnerID=8YFLogxK
U2 - 10.1097/YPG.0b013e328011188b
DO - 10.1097/YPG.0b013e328011188b
M3 - Article
C2 - 17167343
AN - SCOPUS:33845643979
VL - 17
SP - 35
EP - 38
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 1
ER -