Assignment of the gene for human DNA polymerase α to the X chromosome

T. S.F. Wang; B. E. Pearson; H. A. Suomalainen; T. Mohandas; L. J. Shapiro; J. Schröder; D. Korn

doi:10.1073/pnas.82.16.5270

Assignment of the gene for human DNA polymerase α to the X chromosome

T. S.F. Wang
, B. E. Pearson
, H. A. Suomalainen
, T. Mohandas
, L. J. Shapiro
, J. Schröder
, D. Korn

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

Original language	English
Pages (from-to)	5270-5274
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	82
Issue number	16
DOIs	https://doi.org/10.1073/pnas.82.16.5270
State	Published - 1985

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abstract = "We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.",

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year = "1985",

doi = "10.1073/pnas.82.16.5270",

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T1 - Assignment of the gene for human DNA polymerase α to the X chromosome

AU - Wang, T. S.F.

AU - Pearson, B. E.

AU - Suomalainen, H. A.

AU - Mohandas, T.

AU - Shapiro, L. J.

AU - Schröder, J.

AU - Korn, D.

PY - 1985

Y1 - 1985

N2 - We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

AB - We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

UR - https://www.scopus.com/pages/publications/0021848595

U2 - 10.1073/pnas.82.16.5270

DO - 10.1073/pnas.82.16.5270

M3 - Article

C2 - 2410918

AN - SCOPUS:0021848595

SN - 0027-8424

VL - 82

SP - 5270

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 16

ER -

Assignment of the gene for human DNA polymerase α to the X chromosome

Abstract

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