We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - 1985|