Assignment of the gene for human DNA polymerase α to the X chromosome

T. S.F. Wang, B. E. Pearson, H. A. Suomalainen, T. Mohandas, L. J. Shapiro, J. Schröder, D. Korn

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    39 Scopus citations


    We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

    Original languageEnglish
    Pages (from-to)5270-5274
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Issue number16
    StatePublished - 1985


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