Assignment of the gene for human DNA polymerase α to the X chromosome

T. S.F. Wang; B. E. Pearson; H. A. Suomalainen; T. Mohandas; L. J. Shapiro; J. Schröder; D. Korn

doi:10.1073/pnas.82.16.5270

Assignment of the gene for human DNA polymerase α to the X chromosome

T. S.F. Wang, B. E. Pearson, H. A. Suomalainen, T. Mohandas, L. J. Shapiro, J. Schröder, D. Korn

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Abstract

We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

Original language	English
Pages (from-to)	5270-5274
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	82
Issue number	16
DOIs	https://doi.org/10.1073/pnas.82.16.5270
State	Published - 1985

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abstract = "We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.",

author = "Wang, {T. S.F.} and Pearson, {B. E.} and Suomalainen, {H. A.} and T. Mohandas and Shapiro, {L. J.} and J. Schr{\"o}der and D. Korn",

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AU - Wang, T. S.F.

AU - Pearson, B. E.

AU - Suomalainen, H. A.

AU - Mohandas, T.

AU - Shapiro, L. J.

AU - Schröder, J.

AU - Korn, D.

PY - 1985

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AB - We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase α in rodent-human somatic cell hybrid clones to identify a single geneetic locus that is both necessary and sufficient for the expression of DNA polymerase α. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 16

ER -

Assignment of the gene for human DNA polymerase α to the X chromosome

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