@article{890dab94336547aa908e094adc1c2839,
title = "Assessment of the genetic variance of late-onset Alzheimer's disease",
abstract = "Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance explained by genetics; (2) calculate genetic variance explained by known AD single nucleotide polymorphisms (SNPs); and (3) identify the genomic locations of variation that explain the remaining unexplained genetic variance. In total, 53.24% of phenotypic variance is explained by genetics, but known AD SNPs only explain 30.62% of the genetic variance. Of the unexplained genetic variance, approximately 41% is explained by unknown SNPs in regions adjacent to known AD SNPs, and the remaining unexplained genetic variance outside these regions.",
keywords = "Alzheimer's disease, Genetic variance, Genetics",
author = "{Alzheimer's Disease Genetics Consortium (ADGC)} and Adams, {Perrie M.} and Albert, {Marilyn S.} and Albin, {Roger L.} and Apostolova, {Liana G.} and Arnold, {Steven E.} and Sanjay Asthana and Atwood, {Craig S.} and Baldwin, {Clinton T.} and Barber, {Robert C.} and Barmada, {Michael M.} and Barnes, {Lisa L.} and Sandra Barral and Beach, {Thomas G.} and Becker, {James T.} and Beecham, {Gary W.} and Duane Beekly and Bennett, {David A.} and Bigio, {Eileen H.} and Bird, {Thomas D.} and Deborah Blacker and Boeve, {Bradley F.} and Bowen, {James D.} and Adam Boxer and Burke, {James R.} and Burns, {Jeffrey M.} and Buxbaum, {Joseph D.} and Cairns, {Nigel J.} and Cantwell, {Laura B.} and Chuanhai Cao and Carlson, {Chris S.} and Carlsson, {Cynthia M.} and Carney, {Regina M.} and Carrasquillo, {Minerva M.} and Carroll, {Steven L.} and Chui, {Helena C.} and Clark, {David G.} and Jason Corneveaux and David, {Cribbs H.} and Crocco, {Elizabeth A.} and Carlos Cruchaga and {De Jager}, {Philip L.} and Charles DeCarli and {Yesim Demirci}, F. and Malcolm Dick and Dickson, {Dennis W.} and Doody, {Rachelle S.} and Ranjan Duara and Nilufer Ertekin-Taner and Evans, {Denis A.} and Morris, {John C.}",
note = "Publisher Copyright: {\textcopyright} 2016 The Authors.",
year = "2016",
month = may,
day = "1",
doi = "10.1016/j.neurobiolaging.2016.02.024",
language = "English",
volume = "41",
pages = "200.e13--200.e20",
journal = "Neurobiology of Aging",
issn = "0197-4580",
}