Assessment of the Albumin-Bilirubin (ALBI) Grade as a Prognostic Indicator for Hepatocellular Carcinoma Patients Treated with Radioembolization

Bin Gui, Ashley A. Weiner, John Nosher, Shou En Lu, Gretchen M. Foltz, Omar Hasan, Seung K. Kim, Vyacheslav Gendel, Naganathan B. Mani, Darren R. Carpizo, Nael E. Saad, Timothy J. Kennedy, Darryl A. Zuckerman, Jeffrey R. Olsen, Parag J. Parikh, Salma K. Jabbour

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Objective: As the utility of Child-Pugh (C-P) class is limited by the subjectivity of ascites and encephalopathy, we evaluated a previously established objective method, the albumin-bilirubin (ALBI) grade, as a prognosticator for yttrium-90 radioembolization (RE) treatment for patients with hepatocellular carcinoma (HCC). Materials and Methods: A total of 117 patients who received RE for HCC from 2 academic centers were reviewed and stratified by ALBI grade, C-P class, and Barcelona Clinic Liver Cancer stage. The overall survival (OS) according to these 3 criteria was evaluated by Kaplan-Meier survival analysis. The utilities of C-P class and ALBI grade as prognostic indicators were compared using the log-rank test. Multivariate Cox regression analysis was performed to identify additional predictive factors. Results: Patients with ALBI grade 1 (n=49) had superior OS than those with ALBI grade 2 (n=65) (P=0.01). Meanwhile, no significant difference was observed in OS between C-P class A (n=100) and C-P class B (n=14) (P=0.11). For C-P class A patients, the ALBI grade (1 vs. 2) was able to stratify 2 clear and nonoverlapping subgroups with differing OS curves (P=0.03). Multivariate Cox regression test identified alanine transaminase, Barcelona Clinic Liver Cancer stage, and ALBI grade as the strongest prognostic factors for OS (P<0.10). Conclusions: ALBI grade as a prognosticator has demonstrated clear survival discrimination that is superior to C-P class among HCC patients treated with RE, particularly within the subgroup of C-P class A patients. ALBI grade is useful for clinicians to make decisions as to whether RE should be recommended to patients with HCC.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number9
StatePublished - Sep 1 2018


  • albumin-bilirubin (ALBI) grade
  • hepatocellular carcinoma
  • prognostic indicator
  • yttrium-90 radioembolization


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