TY - JOUR
T1 - Assessment of sex differences for multifactorial traits using path analysis
T2 - application to learning difficulties
AU - Rice, John P.
AU - Nichols, Paul L.
AU - Gottesman, Irving I.
N1 - Funding Information:
Acknowledgment. The research reported was supported in part by USPHS AA-03539, MH-25430, and MH-31302.
PY - 1981/6
Y1 - 1981/6
N2 - A general model of multifactorial inheritance is described which allows for sex-specific transmission from parent to offspring, sex-specific correlations in the rearing environments of full siblings, and different prevalences for males and females for qualitative traits. Formulas for the correlations between several types of relatives are given in terms of an underlying path model, and a computer program, available upon request, is described. The model is applied to the Collaborative Perinatal Project sample of siblings and first cousins of children with learning difficulties. No sex differences were found either in transmission or in correlated sibling environments for learning difficulties. Evidence is given that the correlation between the rearing environments of siblings is negative, possibly due to differential allocation of family resources.
AB - A general model of multifactorial inheritance is described which allows for sex-specific transmission from parent to offspring, sex-specific correlations in the rearing environments of full siblings, and different prevalences for males and females for qualitative traits. Formulas for the correlations between several types of relatives are given in terms of an underlying path model, and a computer program, available upon request, is described. The model is applied to the Collaborative Perinatal Project sample of siblings and first cousins of children with learning difficulties. No sex differences were found either in transmission or in correlated sibling environments for learning difficulties. Evidence is given that the correlation between the rearing environments of siblings is negative, possibly due to differential allocation of family resources.
KW - Multifactorial model
KW - learning difficulties
KW - path analysis
KW - sex differences
UR - http://www.scopus.com/inward/record.url?scp=0019488737&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(81)90032-9
DO - 10.1016/0165-1781(81)90032-9
M3 - Article
C2 - 6943596
AN - SCOPUS:0019488737
SN - 0165-1781
VL - 4
SP - 301
EP - 312
JO - Psychiatry Research
JF - Psychiatry Research
IS - 3
ER -