Assessment of regional differences in myocardial blood flow using T2-weighted 3D BOLD imaging

Kara B. Wright, Francis J. Klocke, Vibhas S. Deshpande, Jie Zheng, Kathleen R. Harris, Richard Tang, J. Paul Finn, Debiao Li

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The feasibility of detecting regional differences in myocardial blood flow based on the blood oxygen level-dependent (BOLD) effect was evaluated in vivo in dogs (N = 9) using a 3D T2prepared segmented gradient-echo sequence at 1.5T. Regional differences in myocardial blood flow were created by administering adenosine through a catheter placed in the left circumflex coronary artery (LCX). The difference in the R2 (1/T2) relaxation rate between the left ventricular myocardial region supplied by the LCX and regions supplied by the left anterior descending coronary artery (LAD) or septal artery during adenosine administration was correlated to the corresponding regional myocardial blood flow difference determined using fluorescent microspheres. A correlation coefficient of 0.80 was found between the MR BOLD measurements and the myocardial flow assessment. Our results show that the sequence used in this study allows fast 3D BOLD imaging of the heart, and is a promising technique for detecting regional myocardial perfusion differences.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalMagnetic resonance in medicine
Issue number3
StatePublished - 2001


  • Blood oxygenation
  • Heart
  • Magnetic resonance imaging
  • Perfusion
  • T-weighted imaging


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