Assessment of regional differences in myocardial blood flow using T2-weighted 3D BOLD imaging

Kara B. Wright; Francis J. Klocke; Vibhas S. Deshpande; Jie Zheng; Kathleen R. Harris; Richard Tang; J. Paul Finn; Debiao Li

doi:10.1002/mrm.1229

Assessment of regional differences in myocardial blood flow using T₂-weighted 3D BOLD imaging

Kara B. Wright, Francis J. Klocke, Vibhas S. Deshpande, Jie Zheng, Kathleen R. Harris, Richard Tang, J. Paul Finn, Debiao Li

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The feasibility of detecting regional differences in myocardial blood flow based on the blood oxygen level-dependent (BOLD) effect was evaluated in vivo in dogs (N = 9) using a 3D T₂prepared segmented gradient-echo sequence at 1.5T. Regional differences in myocardial blood flow were created by administering adenosine through a catheter placed in the left circumflex coronary artery (LCX). The difference in the R₂ (1/T₂) relaxation rate between the left ventricular myocardial region supplied by the LCX and regions supplied by the left anterior descending coronary artery (LAD) or septal artery during adenosine administration was correlated to the corresponding regional myocardial blood flow difference determined using fluorescent microspheres. A correlation coefficient of 0.80 was found between the MR BOLD measurements and the myocardial flow assessment. Our results show that the sequence used in this study allows fast 3D BOLD imaging of the heart, and is a promising technique for detecting regional myocardial perfusion differences.

Original language	English
Pages (from-to)	573-578
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	46
Issue number	3
DOIs	https://doi.org/10.1002/mrm.1229
State	Published - 2001

Keywords

Blood oxygenation
Heart
Magnetic resonance imaging
Perfusion
T-weighted imaging

Access to Document

10.1002/mrm.1229

Cite this

@article{b260e83703d04be680f4b1dc43f2a841,

title = "Assessment of regional differences in myocardial blood flow using T2-weighted 3D BOLD imaging",

abstract = "The feasibility of detecting regional differences in myocardial blood flow based on the blood oxygen level-dependent (BOLD) effect was evaluated in vivo in dogs (N = 9) using a 3D T2prepared segmented gradient-echo sequence at 1.5T. Regional differences in myocardial blood flow were created by administering adenosine through a catheter placed in the left circumflex coronary artery (LCX). The difference in the R2 (1/T2) relaxation rate between the left ventricular myocardial region supplied by the LCX and regions supplied by the left anterior descending coronary artery (LAD) or septal artery during adenosine administration was correlated to the corresponding regional myocardial blood flow difference determined using fluorescent microspheres. A correlation coefficient of 0.80 was found between the MR BOLD measurements and the myocardial flow assessment. Our results show that the sequence used in this study allows fast 3D BOLD imaging of the heart, and is a promising technique for detecting regional myocardial perfusion differences.",

keywords = "Blood oxygenation, Heart, Magnetic resonance imaging, Perfusion, T-weighted imaging",

author = "Wright, {Kara B.} and Klocke, {Francis J.} and Deshpande, {Vibhas S.} and Jie Zheng and Harris, {Kathleen R.} and Richard Tang and Finn, {J. Paul} and Debiao Li",

year = "2001",

doi = "10.1002/mrm.1229",

language = "English",

volume = "46",

pages = "573--578",

journal = "Magnetic resonance in medicine",

issn = "0740-3194",

number = "3",

}

TY - JOUR

T1 - Assessment of regional differences in myocardial blood flow using T2-weighted 3D BOLD imaging

AU - Wright, Kara B.

AU - Klocke, Francis J.

AU - Deshpande, Vibhas S.

AU - Zheng, Jie

AU - Harris, Kathleen R.

AU - Tang, Richard

AU - Finn, J. Paul

AU - Li, Debiao

PY - 2001

Y1 - 2001

N2 - The feasibility of detecting regional differences in myocardial blood flow based on the blood oxygen level-dependent (BOLD) effect was evaluated in vivo in dogs (N = 9) using a 3D T2prepared segmented gradient-echo sequence at 1.5T. Regional differences in myocardial blood flow were created by administering adenosine through a catheter placed in the left circumflex coronary artery (LCX). The difference in the R2 (1/T2) relaxation rate between the left ventricular myocardial region supplied by the LCX and regions supplied by the left anterior descending coronary artery (LAD) or septal artery during adenosine administration was correlated to the corresponding regional myocardial blood flow difference determined using fluorescent microspheres. A correlation coefficient of 0.80 was found between the MR BOLD measurements and the myocardial flow assessment. Our results show that the sequence used in this study allows fast 3D BOLD imaging of the heart, and is a promising technique for detecting regional myocardial perfusion differences.

AB - The feasibility of detecting regional differences in myocardial blood flow based on the blood oxygen level-dependent (BOLD) effect was evaluated in vivo in dogs (N = 9) using a 3D T2prepared segmented gradient-echo sequence at 1.5T. Regional differences in myocardial blood flow were created by administering adenosine through a catheter placed in the left circumflex coronary artery (LCX). The difference in the R2 (1/T2) relaxation rate between the left ventricular myocardial region supplied by the LCX and regions supplied by the left anterior descending coronary artery (LAD) or septal artery during adenosine administration was correlated to the corresponding regional myocardial blood flow difference determined using fluorescent microspheres. A correlation coefficient of 0.80 was found between the MR BOLD measurements and the myocardial flow assessment. Our results show that the sequence used in this study allows fast 3D BOLD imaging of the heart, and is a promising technique for detecting regional myocardial perfusion differences.

KW - Blood oxygenation

KW - Heart

KW - Magnetic resonance imaging

KW - Perfusion

KW - T-weighted imaging

UR - http://www.scopus.com/inward/record.url?scp=0034844551&partnerID=8YFLogxK

U2 - 10.1002/mrm.1229

DO - 10.1002/mrm.1229

M3 - Article

C2 - 11550251

AN - SCOPUS:0034844551

SN - 0740-3194

VL - 46

SP - 573

EP - 578

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 3

ER -

Assessment of regional differences in myocardial blood flow using T₂-weighted 3D BOLD imaging

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this