Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin; Natalie J. DelRocco; Emily Hibbitts; Meenakshi Devidas; Moira K. Whitley; Caroline E. Mohrmann; Reuven J. Schore; Elizabeth Raetz; Naomi J. Winick; Stephen P. Hunger; Mignon L. Loh; Marilyn J. Hockenberry; Xiaomei Ma; Anne L. Angiolillo; Kirsten K. Ness; John A. Kairalla; Nina S. Kadan-Lottick

doi:10.1002/pbc.30634

Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin
, Natalie J. DelRocco
, Emily Hibbitts
, Meenakshi Devidas
, Moira K. Whitley
, Caroline E. Mohrmann
, Reuven J. Schore
, Elizabeth Raetz
, Naomi J. Winick
, Stephen P. Hunger
, Mignon L. Loh
, Marilyn J. Hockenberry
, Xiaomei Ma
, Anne L. Angiolillo
, Kirsten K. Ness
, John A. Kairalla
, Nina S. Kadan-Lottick

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

Original language	English
Article number	e30634
Journal	Pediatric Blood and Cancer
Volume	70
Issue number	11
DOIs	https://doi.org/10.1002/pbc.30634
State	Published - Nov 2023

Keywords

chemotherapy-induced peripheral neuropathy
motor neuropathy
pediatric acute lymphoblastic leukemia
proxy-reported surveys
sensory neuropathy

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10.1002/pbc.30634

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Rodwin, R. L., DelRocco, N. J., Hibbitts, E., Devidas, M., Whitley, M. K., Mohrmann, C. E., Schore, R. J., Raetz, E., Winick, N. J., Hunger, S. P., Loh, M. L., Hockenberry, M. J., Ma, X., Angiolillo, A. L., Ness, K. K., Kairalla, J. A., & Kadan-Lottick, N. S. (2023). Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia. Pediatric Blood and Cancer, 70(11), Article e30634. https://doi.org/10.1002/pbc.30634

@article{abbcce028db347ed9b0c12baa353bea5,

title = "Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia",

abstract = "Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95\% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95\% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.",

keywords = "chemotherapy-induced peripheral neuropathy, motor neuropathy, pediatric acute lymphoblastic leukemia, proxy-reported surveys, sensory neuropathy",

author = "Rodwin, \{Rozalyn L.\} and DelRocco, \{Natalie J.\} and Emily Hibbitts and Meenakshi Devidas and Whitley, \{Moira K.\} and Mohrmann, \{Caroline E.\} and Schore, \{Reuven J.\} and Elizabeth Raetz and Winick, \{Naomi J.\} and Hunger, \{Stephen P.\} and Loh, \{Mignon L.\} and Hockenberry, \{Marilyn J.\} and Xiaomei Ma and Angiolillo, \{Anne L.\} and Ness, \{Kirsten K.\} and Kairalla, \{John A.\} and Kadan-Lottick, \{Nina S.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = nov,

doi = "10.1002/pbc.30634",

language = "English",

volume = "70",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

number = "11",

}

Rodwin, RL, DelRocco, NJ, Hibbitts, E, Devidas, M, Whitley, MK, Mohrmann, CE, Schore, RJ, Raetz, E, Winick, NJ, Hunger, SP, Loh, ML, Hockenberry, MJ, Ma, X, Angiolillo, AL, Ness, KK, Kairalla, JA & Kadan-Lottick, NS 2023, 'Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia', Pediatric Blood and Cancer, vol. 70, no. 11, e30634. https://doi.org/10.1002/pbc.30634

TY - JOUR

T1 - Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

AU - Rodwin, Rozalyn L.

AU - DelRocco, Natalie J.

AU - Hibbitts, Emily

AU - Devidas, Meenakshi

AU - Whitley, Moira K.

AU - Mohrmann, Caroline E.

AU - Schore, Reuven J.

AU - Raetz, Elizabeth

AU - Winick, Naomi J.

AU - Hunger, Stephen P.

AU - Loh, Mignon L.

AU - Hockenberry, Marilyn J.

AU - Ma, Xiaomei

AU - Angiolillo, Anne L.

AU - Ness, Kirsten K.

AU - Kairalla, John A.

AU - Kadan-Lottick, Nina S.

PY - 2023/11

Y1 - 2023/11

N2 - Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

AB - Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

KW - chemotherapy-induced peripheral neuropathy

KW - motor neuropathy

KW - pediatric acute lymphoblastic leukemia

KW - proxy-reported surveys

KW - sensory neuropathy

UR - https://www.scopus.com/pages/publications/85168276608

U2 - 10.1002/pbc.30634

DO - 10.1002/pbc.30634

M3 - Article

C2 - 37592363

AN - SCOPUS:85168276608

SN - 1545-5009

VL - 70

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 11

M1 - e30634

ER -

Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

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Keywords

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