Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin, Natalie J. DelRocco, Emily Hibbitts, Meenakshi Devidas, Moira K. Whitley, Caroline E. Mohrmann, Reuven J. Schore, Elizabeth Raetz, Naomi J. Winick, Stephen P. Hunger, Mignon L. Loh, Marilyn J. Hockenberry, Xiaomei Ma, Anne L. Angiolillo, Kirsten K. Ness, John A. Kairalla, Nina S. Kadan-Lottick

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

Original languageEnglish
Article numbere30634
JournalPediatric Blood and Cancer
Volume70
Issue number11
DOIs
StatePublished - Nov 2023

Keywords

  • chemotherapy-induced peripheral neuropathy
  • motor neuropathy
  • pediatric acute lymphoblastic leukemia
  • proxy-reported surveys
  • sensory neuropathy

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