TY - JOUR
T1 - Assessment of neuroplasticity in late-life depression with transcranial magnetic stimulation
AU - Bhandari, Apoorva
AU - Lissemore, Jennifer I.
AU - Rajji, Tarek K.
AU - Mulsant, Benoit H.
AU - Cash, Robin F.H.
AU - Noda, Yoshihiro
AU - Zomorrodi, Reza
AU - Karp, Jordan F.
AU - Lenze, Eric J.
AU - Reynolds, Charles F.
AU - Daskalakis, Zafiris J.
AU - Blumberger, Daniel M.
N1 - Funding Information:
This study was funded in part by a Brain and Behaviour Research Foundation New Investigator Award (DMB) , the Canadian Institutes of Health Research and the National Institutes of Health ( R01MH083643 , R34MH101365 ). We would also like to acknowledge the Temerty Centre and the Canada Foundation for Innovation for providing TMS equipment.
Funding Information:
AB, JIL, RZ and RFHC report no biomedical interests or conflicts. TKR receives research support from Brain Canada, Brain and Behavior Research Foundation, Canada Foundation for Innovation, the CIHR, Ontario Ministry of Health and Long-Term Care, Ontario Ministry of Research and Innovation, the NIH, and the W. Garfield Weston Foundation. BHM currently receives research funding from Brain Canada, the Centre for Addiction and Mental Health (CAMH) Foundation, the Canadian Institutes of Health Research (CIHR), Patient-Centered Outcomes Research Institute (PCORI), and the US National Institute of Health (NIH). During the last five years, he also received research support from Bristol-Myers Squibb (medications for a NIH-funded clinical trial), Eli-Lilly (medications for a NIH-funded clinical trial), and Pfizer (medications for a NIH-funded clinical trial). He directly own stocks of General Electric (less than $5000). EJL reports research funding (current/past) from Janssen, Alkermes, Acadia, Takeda, Lundbeck, Barnes Jewish Foundation, PCORI, and Taylor Family Institute for Innovative Psychiatric Research. CFR has received research support from the NIH, PCORI, the Center for Medicare and Medicaid Services, the American Foundation for Suicide Prevention, the Brain and Behavior Research Foundation, and the Commonwealth of Pennsylvania. Bristol Meyers Squib and Pfizer have provided pharmaceutical supplies for his NIH sponsored research. JFK received medication supplies from Indivior to support this investigator initiated trial. He has also received medication supplies from Pfizer for investigator initiated work. JFK receives research funding from NIH and PCORI. YN has received equipment-in-kind support for an investigator-initiated study from Magventure Inc. He has also received research support from Otsuka Pharmaceutical Co., Ltd., Shionogi & Co. Ltd.., and Meiji Seika Pharma Co., Ltd. YN has received research support from Meiji Yasuda Mental Health Foundation. ZJD has received within the last 3 years both research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. ZJD has also received monies for participation on an advisory board from Sunovion Inc. Finally, ZJD owns >$10,000 (CAD) in stock of Biogen Inc. DMB has received research support from CIHR, NIH, Brain Canada, PCORI, Weston Brain Institute and the Temerty Family through the CAMH Foundation and the Campbell Research Institute. He receives research support and in-kind equipment support for an investigator-initiated study from Brainsway Ltd. and he is the site principal investigator for three sponsor-initiated studies for Brainsway Ltd. He also receives in-kind equipment support from Magventure for an investigator-initiated study. He received medication supplies for an investigator-initiated trial from Indivior.
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Background: Studies using Transcranial Magnetic Stimulation (TMS), a non-invasive method of brain stimulation, have implicated impaired neuroplasticity in the pathophysiology of depression in younger adults. The role of neuroplasticity in late-life depression (LLD) has not yet been explored using TMS. Objective: This study aimed at evaluating motor cortical neuroplasticity using paired associative stimulation (PAS). Single-pulse TMS was used to induce motor-evoked potentials (MEP) in the contralateral hand muscle before and after PAS. The potentiation of MEP amplitudes after PAS was used as an indirect index of associative plasticity and long-term potentiation (LTP) (i.e. PAS-LTP). Results: 48 older adults with depression and 34 age-matched healthy controls (HC) were compared. PAS- LTP was successfully induced in 68.8% of older adults with depression and 47.1% of HC. At the group level, older adults with depression failed to show statistically significant induction of neuroplasticity, which was observed in HC. However, no significant differences were observed between the two groups for PAS-LTP. Conclusion: Our results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD.
AB - Background: Studies using Transcranial Magnetic Stimulation (TMS), a non-invasive method of brain stimulation, have implicated impaired neuroplasticity in the pathophysiology of depression in younger adults. The role of neuroplasticity in late-life depression (LLD) has not yet been explored using TMS. Objective: This study aimed at evaluating motor cortical neuroplasticity using paired associative stimulation (PAS). Single-pulse TMS was used to induce motor-evoked potentials (MEP) in the contralateral hand muscle before and after PAS. The potentiation of MEP amplitudes after PAS was used as an indirect index of associative plasticity and long-term potentiation (LTP) (i.e. PAS-LTP). Results: 48 older adults with depression and 34 age-matched healthy controls (HC) were compared. PAS- LTP was successfully induced in 68.8% of older adults with depression and 47.1% of HC. At the group level, older adults with depression failed to show statistically significant induction of neuroplasticity, which was observed in HC. However, no significant differences were observed between the two groups for PAS-LTP. Conclusion: Our results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD.
KW - Aging
KW - Late-life depression
KW - Long-term potentiation
KW - N-Methyl-D-Aspartate
KW - Neuroplasticity
KW - Paired associative stimulation
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85053158045&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2018.08.022
DO - 10.1016/j.jpsychires.2018.08.022
M3 - Article
C2 - 30195122
AN - SCOPUS:85053158045
SN - 0022-3956
VL - 105
SP - 63
EP - 70
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -