TY - JOUR
T1 - Assessment of myocardial oxygen extraction fraction and perfusion reserve with BOLD imaging in a canine model with coronary artery stenosis
AU - Zhang, Haosen
AU - Gropler, Robert J.
AU - Li, Debiao
AU - Zheng, Jie
PY - 2007/7
Y1 - 2007/7
N2 - Purpose: To determine the feasibility of T2-weighted BOLD imaging for estimating regional myocardial oxygen extraction fraction (OEF) and approximating perfusion reserve (MPR) simultaneously in a canine model with moderate coronary artery stenosis. Materials and Methods: Eight mongrel dogs with moderate coronary artery stenosis underwent BOLD imaging at rest and during dipyridamole-induced hyperemia, using a turbo spin echo (TSE) sequence. Based on a two-compartment model, myocardial OEFhyperemia was calculated with the corresponding T2. MPR could be approximated based on Fick's law. Results: During responsive hyperemia, a regional hypointensity was observed in the abnormally perfused myocardium, reflecting a relatively smaller myocardial T2 increase (3.06% ± 2.74%, in contrast to 10.19% ± .12% in the normal region). The average OEFs in the normally and abnormally perfused myocardial territories were 0.21 ± .11 and 0.43 ± 0.12, respectively. For the MPR approximated from the BOLD imaging, a strong correlation (R = 0.9) in the normal myocardium and a good correlation (R = 0.6) distal to the stenosis were obtained compared to microsphere results. Conclusion: In a canine model with moderate coronary artery stenosis, TSE-based BOLD imaging can quantitatively estimate the regional OEFhyperemia and approximate the MPR, and can distinguish segments perfused by defected coronary artery.
AB - Purpose: To determine the feasibility of T2-weighted BOLD imaging for estimating regional myocardial oxygen extraction fraction (OEF) and approximating perfusion reserve (MPR) simultaneously in a canine model with moderate coronary artery stenosis. Materials and Methods: Eight mongrel dogs with moderate coronary artery stenosis underwent BOLD imaging at rest and during dipyridamole-induced hyperemia, using a turbo spin echo (TSE) sequence. Based on a two-compartment model, myocardial OEFhyperemia was calculated with the corresponding T2. MPR could be approximated based on Fick's law. Results: During responsive hyperemia, a regional hypointensity was observed in the abnormally perfused myocardium, reflecting a relatively smaller myocardial T2 increase (3.06% ± 2.74%, in contrast to 10.19% ± .12% in the normal region). The average OEFs in the normally and abnormally perfused myocardial territories were 0.21 ± .11 and 0.43 ± 0.12, respectively. For the MPR approximated from the BOLD imaging, a strong correlation (R = 0.9) in the normal myocardium and a good correlation (R = 0.6) distal to the stenosis were obtained compared to microsphere results. Conclusion: In a canine model with moderate coronary artery stenosis, TSE-based BOLD imaging can quantitatively estimate the regional OEFhyperemia and approximate the MPR, and can distinguish segments perfused by defected coronary artery.
KW - BOLD imaging
KW - Hyperemia
KW - Myocardial oxygen extraction fraction
KW - Myocardial perfusion reserve
KW - T
UR - http://www.scopus.com/inward/record.url?scp=34547756855&partnerID=8YFLogxK
U2 - 10.1002/jmri.20964
DO - 10.1002/jmri.20964
M3 - Article
C2 - 17659557
AN - SCOPUS:34547756855
SN - 1053-1807
VL - 26
SP - 72
EP - 79
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -