Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

Guang Yang, Eghbal Amidi, William Chapman, Hongbo Luo, Kexin Huang, Sreyankar Nandy, Atahar Mostafa, K. M. Shihab Uddin, Shuang Zhou, Heba Abdelal, Zahra Alipour, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2020
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510632431
DOIs
StatePublished - 2020
EventPhotons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States
Duration: Feb 2 2020Feb 5 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11240
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2020
CountryUnited States
CitySan Francisco
Period02/2/2002/5/20

Keywords

  • Ex-vivo and in-vivo study
  • High-frequency photoacoustic imaging system
  • Human colorectal cancer
  • Photoacoustic and ultrasound imaging
  • Quantitative analysis

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