Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

Guang Yang; Eghbal Amidi; William Chapman; Hongbo Luo; Kexin Huang; Sreyankar Nandy; Atahar Mostafa; K. M. Shihab Uddin; Shuang Zhou; Heba Abdelal; Zahra Alipour; Deyali Chatterjee; Matthew Mutch; Quing Zhu

doi:10.1117/12.2544424

Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

Guang Yang, Eghbal Amidi, William Chapman, Hongbo Luo, Kexin Huang, Sreyankar Nandy, Atahar Mostafa, K. M. Shihab Uddin, Shuang Zhou, Heba Abdelal, Zahra Alipour, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2020
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510632431
DOIs	https://doi.org/10.1117/12.2544424
State	Published - 2020
Event	Photons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States Duration: Feb 2 2020 → Feb 5 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11240
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2020
Country/Territory	United States
City	San Francisco
Period	02/2/20 → 02/5/20

Keywords

Ex-vivo and in-vivo study
High-frequency photoacoustic imaging system
Human colorectal cancer
Photoacoustic and ultrasound imaging
Quantitative analysis

Access to Document

10.1117/12.2544424

Cite this

Yang, G., Amidi, E., Chapman, W., Luo, H., Huang, K., Nandy, S., Mostafa, A., Shihab Uddin, K. M., Zhou, S., Abdelal, H., Alipour, Z., Chatterjee, D., Mutch, M., & Zhu, Q. (2020). Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2020 Article 112400A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11240). SPIE. https://doi.org/10.1117/12.2544424

@inproceedings{e6195497c4464748a11db9881a4a19de,

title = "Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system",

abstract = "Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.",

keywords = "Ex-vivo and in-vivo study, High-frequency photoacoustic imaging system, Human colorectal cancer, Photoacoustic and ultrasound imaging, Quantitative analysis",

author = "Guang Yang and Eghbal Amidi and William Chapman and Hongbo Luo and Kexin Huang and Sreyankar Nandy and Atahar Mostafa and {Shihab Uddin}, {K. M.} and Shuang Zhou and Heba Abdelal and Zahra Alipour and Deyali Chatterjee and Matthew Mutch and Quing Zhu",

note = "Publisher Copyright: {\textcopyright} 2020 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2020 ; Conference date: 02-02-2020 Through 05-02-2020",

year = "2020",

doi = "10.1117/12.2544424",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",

booktitle = "Photons Plus Ultrasound",

}

Yang, G, Amidi, E, Chapman, W, Luo, H, Huang, K, Nandy, S, Mostafa, A, Shihab Uddin, KM, Zhou, S, Abdelal, H, Alipour, Z, Chatterjee, D, Mutch, M & Zhu, Q 2020, Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 112400A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 02/2/20. https://doi.org/10.1117/12.2544424

Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system. / Yang, Guang; Amidi, Eghbal; Chapman, William et al.
Photons Plus Ultrasound: Imaging and Sensing 2020. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2020. 112400A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11240).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

AU - Yang, Guang

AU - Amidi, Eghbal

AU - Chapman, William

AU - Luo, Hongbo

AU - Huang, Kexin

AU - Nandy, Sreyankar

AU - Mostafa, Atahar

AU - Shihab Uddin, K. M.

AU - Zhou, Shuang

AU - Abdelal, Heba

AU - Alipour, Zahra

AU - Chatterjee, Deyali

AU - Mutch, Matthew

AU - Zhu, Quing

PY - 2020

Y1 - 2020

N2 - Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.

AB - Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.

KW - Ex-vivo and in-vivo study

KW - High-frequency photoacoustic imaging system

KW - Human colorectal cancer

KW - Photoacoustic and ultrasound imaging

KW - Quantitative analysis

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U2 - 10.1117/12.2544424

DO - 10.1117/12.2544424

M3 - Conference contribution

AN - SCOPUS:85082652089

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2020

Y2 - 2 February 2020 through 5 February 2020

ER -

Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system

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Keywords

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