Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner; H. Donald Burns; Robert F. Dannals; Dean F. Wong; Bengt Langström; Timothy Duelfer; J. James Frost; Hayden T. Ravert; Jonathan M. Links; Shelley B. Rosenbloom; Scott E. Lukas; Alfred V. Kramer; Michael J. Kuhar

doi:10.1002/ana.410150715

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner
, H. Donald Burns
, Robert F. Dannals
, Dean F. Wong
, Bengt Langström
, Timothy Duelfer
, J. James Frost
, Hayden T. Ravert
, Jonathan M. Links
, Shelley B. Rosenbloom
, Scott E. Lukas
, Alfred V. Kramer
, Michael J. Kuhar

Precision Radiotheranostics Translation Center (PRTC)

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Annals of neurology
Volume	15
Issue number	1 S
DOIs	https://doi.org/10.1002/ana.410150715
State	Published - 1984

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Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langström, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, S. B., Lukas, S. E., Kramer, A. V., & Kuhar, M. J. (1984). Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone. Annals of neurology, 15(1 S), 79-84. https://doi.org/10.1002/ana.410150715

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title = "Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone",

abstract = "We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.",

author = "Wagner, \{Henry N.\} and Burns, \{H. Donald\} and Dannals, \{Robert F.\} and Wong, \{Dean F.\} and Bengt Langstr{\"o}m and Timothy Duelfer and Frost, \{J. James\} and Ravert, \{Hayden T.\} and Links, \{Jonathan M.\} and Rosenbloom, \{Shelley B.\} and Lukas, \{Scott E.\} and Kramer, \{Alfred V.\} and Kuhar, \{Michael J.\}",

year = "1984",

doi = "10.1002/ana.410150715",

language = "English",

volume = "15",

pages = "79--84",

journal = "Annals of neurology",

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T1 - Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

AU - Wagner, Henry N.

AU - Burns, H. Donald

AU - Dannals, Robert F.

AU - Wong, Dean F.

AU - Langström, Bengt

AU - Duelfer, Timothy

AU - Frost, J. James

AU - Ravert, Hayden T.

AU - Links, Jonathan M.

AU - Rosenbloom, Shelley B.

AU - Lukas, Scott E.

AU - Kramer, Alfred V.

AU - Kuhar, Michael J.

PY - 1984

Y1 - 1984

N2 - We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

AB - We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

UR - https://www.scopus.com/pages/publications/0021341734

U2 - 10.1002/ana.410150715

DO - 10.1002/ana.410150715

M3 - Article

C2 - 6611131

AN - SCOPUS:0021341734

SN - 0364-5134

VL - 15

SP - 79

EP - 84

JO - Annals of neurology

JF - Annals of neurology

IS - 1 S

ER -

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Abstract

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