Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner; H. Donald Burns; Robert F. Dannals; Dean F. Wong; Bengt Langström; Timothy Duelfer; J. James Frost; Hayden T. Ravert; Jonathan M. Links; Shelley B. Rosenbloom; Scott E. Lukas; Alfred V. Kramer; Michael J. Kuhar

doi:10.1002/ana.410150715

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Henry N. Wagner, H. Donald Burns, Robert F. Dannals, Dean F. Wong, Bengt Langström, Timothy Duelfer, J. James Frost, Hayden T. Ravert, Jonathan M. Links, Shelley B. Rosenbloom, Scott E. Lukas, Alfred V. Kramer, Michael J. Kuhar

Precision Radio-Theranostics Translational Laboratories (PRT2L)

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42 Scopus citations

Abstract

We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Annals of neurology
Volume	15
Issue number	1 S
DOIs	https://doi.org/10.1002/ana.410150715
State	Published - 1984

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Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langström, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, S. B., Lukas, S. E., Kramer, A. V., & Kuhar, M. J. (1984). Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone. Annals of neurology, 15(1 S), 79-84. https://doi.org/10.1002/ana.410150715

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year = "1984",

doi = "10.1002/ana.410150715",

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AU - Wagner, Henry N.

AU - Burns, H. Donald

AU - Dannals, Robert F.

AU - Wong, Dean F.

AU - Langström, Bengt

AU - Duelfer, Timothy

AU - Frost, J. James

AU - Ravert, Hayden T.

AU - Links, Jonathan M.

AU - Rosenbloom, Shelley B.

AU - Lukas, Scott E.

AU - Kramer, Alfred V.

AU - Kuhar, Michael J.

PY - 1984

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AB - We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.

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JO - Annals of neurology

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IS - 1 S

ER -

Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone

Abstract

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