TY - JOUR
T1 - Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography
AU - Biton, Inbal E.
AU - Stettner, Noa
AU - Brener, Ori
AU - Erez, Ayelet
AU - Harmelin, Alon
AU - Garbow, Joel R.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations.
AB - Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate-induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations.
KW - MR colonography
KW - T2 map
KW - inflammatory bowel disease
KW - magnetic resonance imaging
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85063634534&partnerID=8YFLogxK
U2 - 10.18383/j.tom.2017.00021
DO - 10.18383/j.tom.2017.00021
M3 - Article
C2 - 30042983
AN - SCOPUS:85063634534
SN - 2379-1381
VL - 4
SP - 4
EP - 13
JO - Tomography (Ann Arbor, Mich.)
JF - Tomography (Ann Arbor, Mich.)
IS - 1
ER -