Assessing Cardiac Metabolism

Heinrich Taegtmeyer; Martin E. Young; Gary D. Lopaschuk; E. Dale Abel; Henri Brunengraber; Victor Darley-Usmar; Christine Des Rosiers; Robert Gerszten; Jan F. Glatz; Julian L. Griffin; Robert J. Gropler; Hermann Georg Holzhuetter; Jorge R. Kizer; E. Douglas Lewandowski; Craig R. Malloy; Stefan Neubauer; Linda R. Peterson; Michael A. Portman; Fabio A. Recchia; Jennifer E. Van Eyk; Thomas J. Wang

doi:10.1161/RES.0000000000000097

Assessing Cardiac Metabolism

Heinrich Taegtmeyer, Martin E. Young, Gary D. Lopaschuk, E. Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F. Glatz, Julian L. Griffin, Robert J. Gropler, Hermann Georg Holzhuetter, Jorge R. Kizer, E. Douglas Lewandowski, Craig R. Malloy, Stefan Neubauer, Linda R. Peterson, Michael A. Portman, Fabio A. Recchia, Jennifer E. Van EykThomas J. Wang

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175 Scopus citations

Abstract

In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

Original language	English
Pages (from-to)	1659-1701
Number of pages	43
Journal	Circulation research
Volume	118
Issue number	10
DOIs	https://doi.org/10.1161/RES.0000000000000097
State	Published - May 13 2016

Keywords

AHA Scientific Statements
metabolic pathways
metabolism, cardiac
molecular biology
radionuclide imaging
systems biology

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10.1161/RES.0000000000000097

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Taegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V., Des Rosiers, C., Gerszten, R., Glatz, J. F., Griffin, J. L., Gropler, R. J., Holzhuetter, H. G., Kizer, J. R., Lewandowski, E. D., Malloy, C. R., Neubauer, S., Peterson, L. R., Portman, M. A., Recchia, F. A., ... Wang, T. J. (2016). Assessing Cardiac Metabolism. Circulation research, 118(10), 1659-1701. https://doi.org/10.1161/RES.0000000000000097

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title = "Assessing Cardiac Metabolism",

abstract = "In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on {"}Assessing Cardiac Metabolism{"} seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.",

keywords = "AHA Scientific Statements, metabolic pathways, metabolism, cardiac, molecular biology, radionuclide imaging, systems biology",

author = "Heinrich Taegtmeyer and Young, {Martin E.} and Lopaschuk, {Gary D.} and Abel, {E. Dale} and Henri Brunengraber and Victor Darley-Usmar and {Des Rosiers}, Christine and Robert Gerszten and Glatz, {Jan F.} and Griffin, {Julian L.} and Gropler, {Robert J.} and Holzhuetter, {Hermann Georg} and Kizer, {Jorge R.} and Lewandowski, {E. Douglas} and Malloy, {Craig R.} and Stefan Neubauer and Peterson, {Linda R.} and Portman, {Michael A.} and Recchia, {Fabio A.} and {Van Eyk}, {Jennifer E.} and Wang, {Thomas J.}",

note = "Publisher Copyright: {\textcopyright} 2016 American Heart Association, Inc.",

year = "2016",

month = may,

day = "13",

doi = "10.1161/RES.0000000000000097",

language = "English",

volume = "118",

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Taegtmeyer, H, Young, ME, Lopaschuk, GD, Abel, ED, Brunengraber, H, Darley-Usmar, V, Des Rosiers, C, Gerszten, R, Glatz, JF, Griffin, JL, Gropler, RJ, Holzhuetter, HG, Kizer, JR, Lewandowski, ED, Malloy, CR, Neubauer, S, Peterson, LR, Portman, MA, Recchia, FA, Van Eyk, JE & Wang, TJ 2016, 'Assessing Cardiac Metabolism', Circulation research, vol. 118, no. 10, pp. 1659-1701. https://doi.org/10.1161/RES.0000000000000097

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AU - Taegtmeyer, Heinrich

AU - Young, Martin E.

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AU - Abel, E. Dale

AU - Brunengraber, Henri

AU - Darley-Usmar, Victor

AU - Des Rosiers, Christine

AU - Gerszten, Robert

AU - Glatz, Jan F.

AU - Griffin, Julian L.

AU - Gropler, Robert J.

AU - Holzhuetter, Hermann Georg

AU - Kizer, Jorge R.

AU - Lewandowski, E. Douglas

AU - Malloy, Craig R.

AU - Neubauer, Stefan

AU - Peterson, Linda R.

AU - Portman, Michael A.

AU - Recchia, Fabio A.

AU - Van Eyk, Jennifer E.

AU - Wang, Thomas J.

PY - 2016/5/13

Y1 - 2016/5/13

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AB - In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

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KW - metabolic pathways

KW - metabolism, cardiac

KW - molecular biology

KW - radionuclide imaging

KW - systems biology

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VL - 118

SP - 1659

EP - 1701

JO - Circulation Research

JF - Circulation Research

IS - 10

ER -

Assessing Cardiac Metabolism

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Keywords

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