Aspirin and colorectal cancer: The promise of precision chemoprevention

David A. Drew, Yin Cao, Andrew T. Chan

Research output: Contribution to journalReview articlepeer-review

254 Scopus citations

Abstract

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades of research have provided considerable evidence demonstrating its potential for the prevention of cancer, particularly colorectal cancer. Broader clinical recommendations for aspirin-based chemoprevention strategies have recently been established; however, given the known hazards of long-term aspirin use, larger-scale adoption of an aspirin chemoprevention strategy is likely to require improved identification of individuals for whom the protective benefits outweigh the harms. Such a precision medicine approach may emerge through further clarification of aspirin's mechanism of action.

Original languageEnglish
Pages (from-to)173-186
Number of pages14
JournalNature Reviews Cancer
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2016

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