Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

Roland E. Dolle; Jasbir Singh; James Rinker; Denton Hoyer; C. V.C. Prasad; Todd L. Graybill; Joseph M. Salvino; Carla T. Helaszek; Robert E. Miller; Mark A. Ator

doi:10.1021/jm00049a001

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

Roland E. Dolle
, Jasbir Singh
, James Rinker
, Denton Hoyer
, C. V.C. Prasad
, Todd L. Graybill
, Joseph M. Salvino
, Carla T. Helaszek
, Robert E. Miller
, Mark A. Ator

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3863-3866
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	37
Issue number	23
DOIs	https://doi.org/10.1021/jm00049a001
State	Published - Nov 1 1994

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10.1021/jm00049a001

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Dolle, R. E., Singh, J., Rinker, J., Hoyer, D., Prasad, C. V. C., Graybill, T. L., Salvino, J. M., Helaszek, C. T., Miller, R. E., & Ator, M. A. (1994). Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding. Journal of Medicinal Chemistry, 37(23), 3863-3866. https://doi.org/10.1021/jm00049a001

@article{0df7e9cad66b4b458146df4bd0da42b9,

title = "Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding",

author = "Dolle, \{Roland E.\} and Jasbir Singh and James Rinker and Denton Hoyer and Prasad, \{C. V.C.\} and Graybill, \{Todd L.\} and Salvino, \{Joseph M.\} and Helaszek, \{Carla T.\} and Miller, \{Robert E.\} and Ator, \{Mark A.\}",

year = "1994",

month = nov,

day = "1",

doi = "10.1021/jm00049a001",

language = "English",

volume = "37",

pages = "3863--3866",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

number = "23",

}

Dolle, RE, Singh, J, Rinker, J, Hoyer, D, Prasad, CVC, Graybill, TL, Salvino, JM, Helaszek, CT, Miller, RE & Ator, MA 1994, 'Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding', Journal of Medicinal Chemistry, vol. 37, no. 23, pp. 3863-3866. https://doi.org/10.1021/jm00049a001

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding. / Dolle, Roland E.; Singh, Jasbir; Rinker, James et al.
In: Journal of Medicinal Chemistry, Vol. 37, No. 23, 01.11.1994, p. 3863-3866.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

AU - Dolle, Roland E.

AU - Singh, Jasbir

AU - Rinker, James

AU - Hoyer, Denton

AU - Prasad, C. V.C.

AU - Graybill, Todd L.

AU - Salvino, Joseph M.

AU - Helaszek, Carla T.

AU - Miller, Robert E.

AU - Ator, Mark A.

PY - 1994/11/1

Y1 - 1994/11/1

UR - https://www.scopus.com/pages/publications/0028037148

U2 - 10.1021/jm00049a001

DO - 10.1021/jm00049a001

M3 - Article

C2 - 7966144

AN - SCOPUS:0028037148

SN - 0022-2623

VL - 37

SP - 3863

EP - 3866

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 23

ER -

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

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Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding