Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

Roland E. Dolle; Jasbir Singh; James Rinker; Denton Hoyer; C. V.C. Prasad; Todd L. Graybill; Joseph M. Salvino; Carla T. Helaszek; Robert E. Miller; Mark A. Ator

doi:10.1021/jm00049a001

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

Roland E. Dolle, Jasbir Singh, James Rinker, Denton Hoyer, C. V.C. Prasad, Todd L. Graybill, Joseph M. Salvino, Carla T. Helaszek, Robert E. Miller, Mark A. Ator

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Original language	English
Pages (from-to)	3863-3866
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	37
Issue number	23
DOIs	https://doi.org/10.1021/jm00049a001
State	Published - Nov 1 1994

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10.1021/jm00049a001

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Dolle, R. E., Singh, J., Rinker, J., Hoyer, D., Prasad, C. V. C., Graybill, T. L., Salvino, J. M., Helaszek, C. T., Miller, R. E., & Ator, M. A. (1994). Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding. Journal of Medicinal Chemistry, 37(23), 3863-3866. https://doi.org/10.1021/jm00049a001

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title = "Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding",

author = "Dolle, {Roland E.} and Jasbir Singh and James Rinker and Denton Hoyer and Prasad, {C. V.C.} and Graybill, {Todd L.} and Salvino, {Joseph M.} and Helaszek, {Carla T.} and Miller, {Robert E.} and Ator, {Mark A.}",

year = "1994",

month = nov,

day = "1",

doi = "10.1021/jm00049a001",

language = "English",

volume = "37",

pages = "3863--3866",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

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Dolle, RE, Singh, J, Rinker, J, Hoyer, D, Prasad, CVC, Graybill, TL, Salvino, JM, Helaszek, CT, Miller, RE & Ator, MA 1994, 'Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding', Journal of Medicinal Chemistry, vol. 37, no. 23, pp. 3863-3866. https://doi.org/10.1021/jm00049a001

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding. / Dolle, Roland E.; Singh, Jasbir; Rinker, James et al.
In: Journal of Medicinal Chemistry, Vol. 37, No. 23, 01.11.1994, p. 3863-3866.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

AU - Dolle, Roland E.

AU - Singh, Jasbir

AU - Rinker, James

AU - Hoyer, Denton

AU - Prasad, C. V.C.

AU - Graybill, Todd L.

AU - Salvino, Joseph M.

AU - Helaszek, Carla T.

AU - Miller, Robert E.

AU - Ator, Mark A.

PY - 1994/11/1

Y1 - 1994/11/1

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DO - 10.1021/jm00049a001

M3 - Article

C2 - 7966144

AN - SCOPUS:0028037148

SN - 0022-2623

VL - 37

SP - 3863

EP - 3866

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 23

ER -

Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P1 and P3 Amido Nitrogens for Enzyme–Peptide Inhibitor Binding

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Aspartyl α-((1-Phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl Ketones as Interleukin-1β Converting Enzyme Inhibitors. Significance of the P₁ and P₃ Amido Nitrogens for Enzyme–Peptide Inhibitor Binding