Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets

Graham H. Coombs, Daniel E. Goldberg, Michael Klemba, Colin Berry, John Kay, Jeremy C. Mottram

Research output: Contribution to journalReview article

254 Scopus citations

Abstract

All parasitic protozoa contain multiple proteases, some of which are attracting attention as drug targets. Aspartic proteases are already the targets of some clinically useful drugs (e.g. chemotherapy of HIV infection) and a variety of factors make these enzymes appealing to those seeking novel antiparasite therapies. This review provides a critical analysis of the current knowledge on Plasmodium aspartic proteases termed plasmepsins, proposes a definitive nomenclature for this group of enzymes, and compares these enzymes with aspartic proteases of humans and other parasitic protozoa. The present status of attempts to obtain specific inhibitors of the parasite enzymes that will be useful as drugs is outlined and suggestions for future research priorities are proposed.

Original languageEnglish
Pages (from-to)532-537
Number of pages6
JournalTrends in Parasitology
Volume17
Issue number11
DOIs
StatePublished - Nov 1 2001
Externally publishedYes

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