TY - JOUR
T1 - Aseptic loosening of total joint replacements
T2 - Mechanisms underlying osteolysis and potential therapies
AU - Abu-Amer, Yousef
AU - Darwech, Isra
AU - Clohisy, John C.
PY - 2007/6/29
Y1 - 2007/6/29
N2 - Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is manifested by recruitment of a wide array of cell types. These cells include macrophages, fibroblasts, giant cells, neutrophils, lymphocytes, and - most importantly - osteoclasts, which are the principal bone resorbing cells. The 'cellular response' entails secretion of osteoclastogenic and inflammatory cytokines that favor exacerbated osteoclast activity and enhanced osteolysis. An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
AB - Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is manifested by recruitment of a wide array of cell types. These cells include macrophages, fibroblasts, giant cells, neutrophils, lymphocytes, and - most importantly - osteoclasts, which are the principal bone resorbing cells. The 'cellular response' entails secretion of osteoclastogenic and inflammatory cytokines that favor exacerbated osteoclast activity and enhanced osteolysis. An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
UR - http://www.scopus.com/inward/record.url?scp=34548418499&partnerID=8YFLogxK
U2 - 10.1186/ar2170
DO - 10.1186/ar2170
M3 - Review article
C2 - 17634145
AN - SCOPUS:34548418499
SN - 1478-6354
VL - 9
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
IS - SUPPL.1
M1 - S6
ER -