As a Matter of Fat

Rita T. Brookheart; Carlos I. Michel; Jean E. Schaffer

doi:10.1016/j.cmet.2009.03.011

As a Matter of Fat

Rita T. Brookheart, Carlos I. Michel, Jean E. Schaffer

Research output: Contribution to journal › Short survey › peer-review

226 Scopus citations

Abstract

Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.

Original language	English
Pages (from-to)	9-12
Number of pages	4
Journal	Cell metabolism
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2009.03.011
State	Published - Jul 8 2009

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title = "As a Matter of Fat",

abstract = "Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.",

author = "Brookheart, {Rita T.} and Michel, {Carlos I.} and Schaffer, {Jean E.}",

note = "Funding Information: This work was supported by grants from the NIH (DK064989, DK077583, and DK077577) and the Burroughs Wellcome Foundation (1005935).",

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AU - Michel, Carlos I.

AU - Schaffer, Jean E.

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Y1 - 2009/7/8

N2 - Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.

AB - Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.

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As a Matter of Fat

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