As a Matter of Fat

Rita T. Brookheart, Carlos I. Michel, Jean E. Schaffer

Research output: Contribution to journalShort surveypeer-review

215 Scopus citations


Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalCell metabolism
Issue number1
StatePublished - Jul 8 2009


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