TY - JOUR
T1 - Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons
AU - Honma, Yutaka
AU - Araki, Toshiyuki
AU - Gianino, Scott
AU - Bruce, Allen
AU - Heuckeroth, Robert O.
AU - Johnson, Eugene M.
AU - Milbrandt, Jeffrey
N1 - Funding Information:
We are grateful to J.-F. Brunet for providing anti-Phox2a,b antibodies. We thank H. Enomoto and members of the Milbrandt and Johnson labs for their support and helpful discussions. This work was supported by National Institutes of Health grants AG13730 and NS39358 (to J.M.), AG 13729 (to E.M.J.), K57038-01 (to R.O.H.). R.O.H. is a Scholar of the Child Health Research Center of Excellence in Developmental Biology at Washington University School of Medicine (HD01487).
PY - 2002/7/18
Y1 - 2002/7/18
N2 - Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRα3 receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system. This resulted in abnormal innervation of target tissues and consequent cell death due to deficiencies of target-derived neurotrophic support. ARTN is expressed along blood vessels and in cells nearby to sympathetic axonal projections. In the developing vasculature, ARTN is expressed in smooth muscle cells of the vessels, and it acts as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues. The chemoattractive properties of ARTN were confirmed by the demonstration that sympathetic neuroblasts migrate and project axons toward ARTN-soaked beads implanted into mouse embryos.
AB - Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRα3 receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system. This resulted in abnormal innervation of target tissues and consequent cell death due to deficiencies of target-derived neurotrophic support. ARTN is expressed along blood vessels and in cells nearby to sympathetic axonal projections. In the developing vasculature, ARTN is expressed in smooth muscle cells of the vessels, and it acts as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues. The chemoattractive properties of ARTN were confirmed by the demonstration that sympathetic neuroblasts migrate and project axons toward ARTN-soaked beads implanted into mouse embryos.
UR - http://www.scopus.com/inward/record.url?scp=0037130466&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00774-2
DO - 10.1016/S0896-6273(02)00774-2
M3 - Article
C2 - 12160745
AN - SCOPUS:0037130466
SN - 0896-6273
VL - 35
SP - 267
EP - 282
JO - Neuron
JF - Neuron
IS - 2
ER -