Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons

Yutaka Honma, Toshiyuki Araki, Scott Gianino, Allen Bruce, Robert O. Heuckeroth, Eugene M. Johnson, Jeffrey Milbrandt

Research output: Contribution to journalArticlepeer-review

252 Scopus citations

Abstract

Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRα3 receptor complex. Characterization of ARTN- and GFRα3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system. This resulted in abnormal innervation of target tissues and consequent cell death due to deficiencies of target-derived neurotrophic support. ARTN is expressed along blood vessels and in cells nearby to sympathetic axonal projections. In the developing vasculature, ARTN is expressed in smooth muscle cells of the vessels, and it acts as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues. The chemoattractive properties of ARTN were confirmed by the demonstration that sympathetic neuroblasts migrate and project axons toward ARTN-soaked beads implanted into mouse embryos.

Original languageEnglish
Pages (from-to)267-282
Number of pages16
JournalNeuron
Volume35
Issue number2
DOIs
StatePublished - Jul 18 2002

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