Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3-RET receptor complex

Robert H. Baloh, Malú G. Tansey, Patricia A. Lampe, Timothy J. Fahrner, Hideki Enomoto, Kelli S. Simburger, Melanie L. Leitner, Toshiyuki Araki, Eugene M. Johnson, Jeffrey Milbrandt

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466 Scopus citations

Abstract

The glial cell line-derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a multicomponent receptor system composed of a high-affinity binding component (GFRα1GFRα4) and a common signaling component (RET). Here, we report the identification of Artemin, a novel member of the GDNF family, and demonstrate that it is the ligand for the former orphan receptor GFRα3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also influences these neurons in vivo. Artemin can also activate the GFRα1-RET complex and supports the survival of dopaminergic midbrain neurons in culture, indicating that like GDNF (GFRα1RET) and NTN (GFRα2-RET), Artemin has a preferred receptor (GFRα3- RET) but that alternative receptor interactions also occur.

Original languageEnglish
Pages (from-to)1291-1302
Number of pages12
JournalNeuron
Volume21
Issue number6
DOIs
StatePublished - Dec 1998

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    Baloh, R. H., Tansey, M. G., Lampe, P. A., Fahrner, T. J., Enomoto, H., Simburger, K. S., Leitner, M. L., Araki, T., Johnson, E. M., & Milbrandt, J. (1998). Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3-RET receptor complex. Neuron, 21(6), 1291-1302. https://doi.org/10.1016/S0896-6273(00)80649-2