Arrhythmia triggers in heart failure: The smoking gun of [Ca 2+]i dysregulation

Gary L. Aistrup; C. William Balke; J. Andrew Wasserstrom

doi:10.1016/j.hrthm.2011.06.012

Arrhythmia triggers in heart failure: The smoking gun of [Ca ²⁺]_i dysregulation

Gary L. Aistrup, C. William Balke, J. Andrew Wasserstrom

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.

Original language	English
Pages (from-to)	1804-1808
Number of pages	5
Journal	Heart rhythm
Volume	8
Issue number	11
DOIs	https://doi.org/10.1016/j.hrthm.2011.06.012
State	Published - Nov 2011

Keywords

Calcium alternans
Calcium cycling
Calcium waves
Heart failure

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10.1016/j.hrthm.2011.06.012

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title = "Arrhythmia triggers in heart failure: The smoking gun of [Ca 2+]i dysregulation",

abstract = "Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.",

keywords = "Calcium alternans, Calcium cycling, Calcium waves, Heart failure",

author = "Aistrup, {Gary L.} and Balke, {C. William} and Wasserstrom, {J. Andrew}",

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AU - Balke, C. William

AU - Wasserstrom, J. Andrew

PY - 2011/11

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AB - Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.

KW - Calcium alternans

KW - Calcium cycling

KW - Calcium waves

KW - Heart failure

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ER -

Arrhythmia triggers in heart failure: The smoking gun of [Ca ²⁺]_i dysregulation

Abstract

Keywords

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