Arrhythmia triggers in heart failure: The smoking gun of [Ca 2+]i dysregulation

Gary L. Aistrup, C. William Balke, J. Andrew Wasserstrom

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.

Original languageEnglish
Pages (from-to)1804-1808
Number of pages5
JournalHeart rhythm
Issue number11
StatePublished - Nov 2011


  • Calcium alternans
  • Calcium cycling
  • Calcium waves
  • Heart failure


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