Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication

Thomas A. Kunkel, Peter M.J. Burgers

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Biochemical and cryo-electron microscopy studies have just been published revealing interactions among proteins of the yeast replisome that are important for highly coordinated synthesis of the two DNA strands of the nuclear genome. These studies reveal key interactions important for arranging DNA polymerases α, δ, and ϵ for leading and lagging strand replication. The CMG (Mcm2-7, Cdc45, GINS) helicase is central to this interaction network. These are but the latest examples of elegant studies performed in the recent past that lead to a much better understanding of how the eukaryotic replication fork achieves efficient DNA replication that is accurate enough to prevent diseases yet allows evolution.

Original languageEnglish
Article number1700070
JournalBioEssays
Volume39
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • DNA polymerases
  • DNA replication
  • cryo-electron microscopy
  • initiation of replication
  • replisome

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