Arginine kinase of the flagellate protozoa Trypanosoma cruzi: Regulation of its expression and catalytic activity

Guillermo D. Alonso, Claudio A. Pereira, María S. Remedi, M. Cristina Paveto, Luisa Cochella, M. Soledad Ivaldi, Nelia M. Gerez de Burgos, Héctor N. Torres, Mirtha M. Flawiá

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

In epimastigotes of Trypanosoma cruzi, the etiological agent of Chagas' disease, arginine kinase activity increased continuously during the exponential phase of growth. A correlation between growth rate, enzyme-specific activity and enzyme protein was observed. Arginine kinase-specific activity, expressed as a function of enzyme protein, remains roughly constant up to 18 days of culture. In the whole range of the culture time mRNA levels showed minor changes indicating that the enzyme activity is post-transcriptionally regulated. Arginine kinase could be proposed as a modulator of energetic reserves under starvation stress condition.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalFEBS Letters
Volume498
Issue number1
DOIs
StatePublished - Jun 1 2001

Keywords

  • Arginine kinase
  • Guanidino kinase
  • Phosphagen
  • Phosphoarginine
  • Trypanosoma cruzi

Fingerprint

Dive into the research topics of 'Arginine kinase of the flagellate protozoa Trypanosoma cruzi: Regulation of its expression and catalytic activity'. Together they form a unique fingerprint.

Cite this