TY - JOUR
T1 - ARF tumor suppression in the nucleolus
AU - Maggi, Leonard B.
AU - Winkeler, Crystal L.
AU - Miceli, Alexander P.
AU - Apicelli, Anthony J.
AU - Brady, Suzanne N.
AU - Kuchenreuther, Michael J.
AU - Weber, Jason D.
PY - 2014/6
Y1 - 2014/6
N2 - Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
AB - Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
KW - ARF
KW - Cell cycle
KW - Nucleolus
KW - P53
KW - Ribosome
UR - http://www.scopus.com/inward/record.url?scp=84897047751&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2014.01.016
DO - 10.1016/j.bbadis.2014.01.016
M3 - Review article
C2 - 24525025
AN - SCOPUS:84897047751
SN - 0925-4439
VL - 1842
SP - 831
EP - 839
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 6
ER -