ARF tumor suppression in the nucleolus

Leonard B. Maggi; Crystal L. Winkeler; Alexander P. Miceli; Anthony J. Apicelli; Suzanne N. Brady; Michael J. Kuchenreuther; Jason D. Weber

doi:10.1016/j.bbadis.2014.01.016

ARF tumor suppression in the nucleolus

Leonard B. Maggi, Crystal L. Winkeler, Alexander P. Miceli, Anthony J. Apicelli, Suzanne N. Brady, Michael J. Kuchenreuther, Jason D. Weber

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

Original language	English
Pages (from-to)	831-839
Number of pages	9
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1842
Issue number	6
DOIs	https://doi.org/10.1016/j.bbadis.2014.01.016
State	Published - Jun 2014

Keywords

ARF
Cell cycle
Nucleolus
P53
Ribosome

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10.1016/j.bbadis.2014.01.016

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title = "ARF tumor suppression in the nucleolus",

abstract = "Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.",

keywords = "ARF, Cell cycle, Nucleolus, P53, Ribosome",

author = "Maggi, {Leonard B.} and Winkeler, {Crystal L.} and Miceli, {Alexander P.} and Apicelli, {Anthony J.} and Brady, {Suzanne N.} and Kuchenreuther, {Michael J.} and Weber, {Jason D.}",

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T1 - ARF tumor suppression in the nucleolus

AU - Maggi, Leonard B.

AU - Winkeler, Crystal L.

AU - Miceli, Alexander P.

AU - Apicelli, Anthony J.

AU - Brady, Suzanne N.

AU - Kuchenreuther, Michael J.

AU - Weber, Jason D.

PY - 2014/6

Y1 - 2014/6

N2 - Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

AB - Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

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KW - Cell cycle

KW - Nucleolus

KW - P53

KW - Ribosome

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DO - 10.1016/j.bbadis.2014.01.016

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JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 6

ER -

ARF tumor suppression in the nucleolus

Abstract

Keywords

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