TY - JOUR
T1 - Areas of Metabolomic Exploration for Helminth Infections
AU - Whitman, Jeffrey D.
AU - Sakanari, Judy A.
AU - Mitreva, Makedonka
N1 - Funding Information:
The participation of J.D.W. was supported by a grant from the National Heart, Lung, and Blood Institute at the National Institutes of Health under award number K38HL154203. J.A.S. was supported by the Bill and Melinda Gates Foundation under award number OPP1017584. M.M. was supported by the National Institute of General Medical Sciences Grant R01GM097435. The funding sources had no role in the study design, collection, analysis and interpretation of the data, preparation of the manuscript, or the decision to submit for publication. This publication’s contents are solely the responsibility of the authors and do not necessarily represent the official views of their sponsors.
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/2/12
Y1 - 2021/2/12
N2 - Helminths represent a diverse category of parasitic organisms that can thrive within a host for years, if not decades, in the absence of treatment. As such, they must establish mechanisms to subsist off their hosts, evade the immune system, and develop a niche among the other cohabiting microbial communities. The complex interplay of biologically small molecules (collectively known as the metabolome) derived from, utilized by, or in response to the presence of helminths within a host is an emerging field of study. In this Perspective, we briefly summarize the current existing literature, categorize key host-pathogen-microbiome interfaces that could be studied in the context of the metabolome, and provide background on mass spectrometry-based metabolomic methodology. Overall, we hope to provide a comprehensive guide for utilizing metabolomics in the context of helminthic disease.
AB - Helminths represent a diverse category of parasitic organisms that can thrive within a host for years, if not decades, in the absence of treatment. As such, they must establish mechanisms to subsist off their hosts, evade the immune system, and develop a niche among the other cohabiting microbial communities. The complex interplay of biologically small molecules (collectively known as the metabolome) derived from, utilized by, or in response to the presence of helminths within a host is an emerging field of study. In this Perspective, we briefly summarize the current existing literature, categorize key host-pathogen-microbiome interfaces that could be studied in the context of the metabolome, and provide background on mass spectrometry-based metabolomic methodology. Overall, we hope to provide a comprehensive guide for utilizing metabolomics in the context of helminthic disease.
KW - helminths
KW - immunology
KW - mass spectrometry
KW - metabolomics
KW - microbiome
KW - parasites
UR - http://www.scopus.com/inward/record.url?scp=85100802184&partnerID=8YFLogxK
U2 - 10.1021/acsinfecdis.0c00658
DO - 10.1021/acsinfecdis.0c00658
M3 - Review article
C2 - 33492932
AN - SCOPUS:85100802184
VL - 7
SP - 206
EP - 214
JO - ACS Infectious Diseases
JF - ACS Infectious Diseases
SN - 2373-8227
IS - 2
ER -