Areas of Metabolomic Exploration for Helminth Infections

Jeffrey D. Whitman, Judy A. Sakanari, Makedonka Mitreva

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Helminths represent a diverse category of parasitic organisms that can thrive within a host for years, if not decades, in the absence of treatment. As such, they must establish mechanisms to subsist off their hosts, evade the immune system, and develop a niche among the other cohabiting microbial communities. The complex interplay of biologically small molecules (collectively known as the metabolome) derived from, utilized by, or in response to the presence of helminths within a host is an emerging field of study. In this Perspective, we briefly summarize the current existing literature, categorize key host-pathogen-microbiome interfaces that could be studied in the context of the metabolome, and provide background on mass spectrometry-based metabolomic methodology. Overall, we hope to provide a comprehensive guide for utilizing metabolomics in the context of helminthic disease.

Original languageEnglish
Pages (from-to)206-214
Number of pages9
JournalACS Infectious Diseases
Volume7
Issue number2
DOIs
StatePublished - Feb 12 2021

Keywords

  • helminths
  • immunology
  • mass spectrometry
  • metabolomics
  • microbiome
  • parasites

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