Arachidonic acid 15-lipoxygenase products from human eosinophils

J. Turk, R. L. Maas, A. R. Brash, L. J. Roberts, J. A. Oates

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A series of six derivatives of arachidonic acid containing a conjugated triene system and hydroxyl groups at C-15 and at C-8 or C-14 (15-series leukotrienes) was isolated from eosinophil-rich human leukocyte preparations. Among classes of leukocytes in these preparations, eosinophils were the dominant source of the 15-series leukotrienes. The most abundant arachidonate metabolite recovered from human eosinophils was 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid. This compound was synthesized by a lipoxygenase enzyme and is a reduction product of the precursor to the 15-series leukotrienes (15(S)-hydro-peroxy-5,8,11-cis-13-trans-eicosatetraenoic acid).

Original languageEnglish
Pages (from-to)7068-7076
Number of pages9
JournalJournal of Biological Chemistry
Issue number12
StatePublished - Dec 1 1982
Externally publishedYes

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    Turk, J., Maas, R. L., Brash, A. R., Roberts, L. J., & Oates, J. A. (1982). Arachidonic acid 15-lipoxygenase products from human eosinophils. Journal of Biological Chemistry, 257(12), 7068-7076.