Abstract
A series of six derivatives of arachidonic acid containing a conjugated triene system and hydroxyl groups at C-15 and at C-8 or C-14 (15-series leukotrienes) was isolated from eosinophil-rich human leukocyte preparations. Among classes of leukocytes in these preparations, eosinophils were the dominant source of the 15-series leukotrienes. The most abundant arachidonate metabolite recovered from human eosinophils was 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid. This compound was synthesized by a lipoxygenase enzyme and is a reduction product of the precursor to the 15-series leukotrienes (15(S)-hydro-peroxy-5,8,11-cis-13-trans-eicosatetraenoic acid).
Original language | English |
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Pages (from-to) | 7068-7076 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 257 |
Issue number | 12 |
State | Published - 1982 |