TY - JOUR
T1 - Approaching a consensus cognitive battery for clinical trials in schizophrenia
T2 - The NIMH-MATRICS conference to select cognitive domains and test criteria
AU - Green, Michael F.
AU - Nuechterlein, Keith H.
AU - Gold, James M.
AU - Barch, Deanna M.
AU - Cohen, Jonathan
AU - Essock, Susan
AU - Fenton, Wayne S.
AU - Frese, Fred
AU - Goldberg, Terry E.
AU - Heaton, Robert K.
AU - Keefe, Richard S.E.
AU - Kern, Robert S.
AU - Kraemer, Helena
AU - Stover, Ellen
AU - Weinberger, Daniel R.
AU - Zalcman, Steven
AU - Marder, Stephen R.
N1 - Funding Information:
The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG).
PY - 2004/9/1
Y1 - 2004/9/1
N2 - To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.
AB - To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.
KW - Cognition
KW - cognitive assessment
KW - cognitive enhancement
KW - neurocognition
KW - psychopharmacology
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=4444220908&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2004.06.023
DO - 10.1016/j.biopsych.2004.06.023
M3 - Review article
C2 - 15336511
AN - SCOPUS:4444220908
SN - 0006-3223
VL - 56
SP - 301
EP - 307
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5
ER -