Approaches to oligoribonucleotide synthesis via phosphotriester intermediates

J. H. Van Boom, P. M.J. Burgers, G. R. Owen, C. B. Reese, R. Saffhill

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Methods are described for the synthesis of uridylyl-(3′ → 5′)-uridine and uridylyl-(3′ → 5′)-uridylyl-(3′ → 5′)-uridine, in good yields a phosphotriester approach has been adopted with the internucleotidic linkages protected by aryl protecting groups.

Original languageEnglish
Pages (from-to)869-871
Number of pages3
JournalJournal of the Chemical Society D: Chemical Communications
Issue number15
DOIs
StatePublished - Jan 1 1971

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