TY - JOUR
T1 - Approach to vaccinating the pediatric solid organ transplant candidate and recipient
AU - Kao, Carol M.
AU - Michaels, Marian G.
N1 - Publisher Copyright:
2023 Kao and Michaels.
PY - 2023
Y1 - 2023
N2 - Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is to provide readers with a concise, practical, expert-opinion on the approach to vaccinating the SOT candidate and recipient and to supplement existing guidelines. In addition, pediatric-specific knowledge gaps in the field and future research priorities will be highlighted.
AB - Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is to provide readers with a concise, practical, expert-opinion on the approach to vaccinating the SOT candidate and recipient and to supplement existing guidelines. In addition, pediatric-specific knowledge gaps in the field and future research priorities will be highlighted.
KW - immunizations
KW - pre-transplant evaluation
KW - solid organ transplant
KW - vaccine-preventable infections
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85177599409&partnerID=8YFLogxK
U2 - 10.3389/fped.2023.1271065
DO - 10.3389/fped.2023.1271065
M3 - Article
C2 - 38027303
AN - SCOPUS:85177599409
SN - 2296-2360
VL - 11
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 1271065
ER -