Approach to vaccinating the pediatric solid organ transplant candidate and recipient

Carol M. Kao, Marian G. Michaels

Research output: Contribution to journalArticlepeer-review

Abstract

Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is to provide readers with a concise, practical, expert-opinion on the approach to vaccinating the SOT candidate and recipient and to supplement existing guidelines. In addition, pediatric-specific knowledge gaps in the field and future research priorities will be highlighted.

Original languageEnglish
Article number1271065
JournalFrontiers in Pediatrics
Volume11
DOIs
StatePublished - 2023

Keywords

  • immunizations
  • pre-transplant evaluation
  • solid organ transplant
  • vaccine-preventable infections
  • vaccines

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