Applications of novel HRV techniques to PGC1a-deficient and wild type mice

Phyllis K. Stein, D. W. Lee, J. J. Lehman, A. Gupta

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Graphical plots of beat-by-beat heart rate (HR) patterns, e.g., Poincaré plots, provide information beyond traditional HRV, but such plots have not been used in mice. HR patterns from 3 min recording/ hour in 4 wild type and 4 PGC1α-deficient mice were compared. In comparison to normal mice, knockout mice tended to have lower HRs (694 ± 16 vs. 752 ± 51 bpm) consistent with their decreased ability to use glucose in the heart. Poincaré plots from each hour showed that none of the wild-type mice had abnormal, fan-like, complex patterns in any hour of their recording. However, 3 of the 4 knockout mice had a complex pattern in at least 10 hours of the recording. Results suggest that hourly Poincaré plot analyses from multiple short-term recordings may be useful in identifying cardiac autonomic abnormalities in knockout mouse models. Samples from the entire 24-hour period provide more information about autonomic function than a single brief recording.

Original languageEnglish
Title of host publicationComputers in Cardiology 2009, CinC 2009
Pages61-64
Number of pages4
StatePublished - Dec 1 2009
Event36th Annual Conference of Computers in Cardiology, CinC 2009 - Park City, UT, United States
Duration: Sep 13 2009Sep 16 2009

Publication series

NameComputers in Cardiology
Volume36
ISSN (Print)0276-6574

Conference

Conference36th Annual Conference of Computers in Cardiology, CinC 2009
CountryUnited States
CityPark City, UT
Period09/13/0909/16/09

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