Applications of elastin-like polypeptides in tissue engineering

Dana L. Nettles; Ashutosh Chilkoti; Lori A. Setton

doi:10.1016/j.addr.2010.04.002

Applications of elastin-like polypeptides in tissue engineering

Dana L. Nettles, Ashutosh Chilkoti, Lori A. Setton

Research output: Contribution to journal › Review article › peer-review

302 Scopus citations

Abstract

Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

Original language	English
Pages (from-to)	1479-1485
Number of pages	7
Journal	Advanced Drug Delivery Reviews
Volume	62
Issue number	15
DOIs	https://doi.org/10.1016/j.addr.2010.04.002
State	Published - Dec 30 2010

Keywords

Cartilage
Crosslinking
Elastin
Hydrogel
Liver
Tissue engineering
Vascular graft

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title = "Applications of elastin-like polypeptides in tissue engineering",

abstract = "Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.",

keywords = "Cartilage, Crosslinking, Elastin, Hydrogel, Liver, Tissue engineering, Vascular graft",

author = "Nettles, \{Dana L.\} and Ashutosh Chilkoti and Setton, \{Lori A.\}",

note = "Funding Information: This study was supported by grants from the NIH ( R01EB02263 , P01AR50245 , and R01GM061232 ), and the North Carolina Biotechnology Center . ",

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doi = "10.1016/j.addr.2010.04.002",

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T1 - Applications of elastin-like polypeptides in tissue engineering

AU - Nettles, Dana L.

AU - Chilkoti, Ashutosh

AU - Setton, Lori A.

N1 - Funding Information: This study was supported by grants from the NIH ( R01EB02263 , P01AR50245 , and R01GM061232 ), and the North Carolina Biotechnology Center .

PY - 2010/12/30

Y1 - 2010/12/30

N2 - Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

AB - Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.

KW - Cartilage

KW - Crosslinking

KW - Elastin

KW - Hydrogel

KW - Liver

KW - Tissue engineering

KW - Vascular graft

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DO - 10.1016/j.addr.2010.04.002

M3 - Review article

C2 - 20385185

AN - SCOPUS:78649884694

SN - 0169-409X

VL - 62

SP - 1479

EP - 1485

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 15

ER -

Applications of elastin-like polypeptides in tissue engineering

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Keywords

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