@article{fc276dd432c447b780df4cdf1e4677ed,
title = "Application of SDOC cut points for low muscle strength for recovery of walking speed after hip fracture",
abstract = "Background: Sarcopenia is often conceptualized as a precursor to loss of mobility, but its effect on recovery of mobility after a hip fracture is unknown. We determined the prevalence of low muscle strength (weakness) after hip fracture using putative sarcopenia metrics (absolute grip strength, and grip strength normalized to body mass index, total body fat, arm lean mass, and weight) identified by the Sarcopenia Definitions and Outcomes Consortium (SDOC). Methods: We examined two well-characterized hip fracture cohorts of community-dwelling older adults from the Baltimore Hip Studies (BHS). The prevalence of muscle weakness was assessed using the SDOC cut points compared to published definitions at 2 and 6 months postfracture. We assessed associations of 2-month weakness with 6-month walking speed <0.6 m/s and calculated the sensitivity and specificity in predicting lack of meaningful change in walking speed (change < 0.1 m/s) at 6 months. Results: Two hundred and forty-six participants (192 women; 54 men) were included; mean (SD) age of 81 (8) for women and 78 (7) for men. At 2 months, 91% women and 78% men exhibited slow walking speed (< 0.6 m/s). SDOC grip strength standardized by weight (<0.34 kg women, <0.45 kg men) was the most prevalent measure of weakness in men (74%) and women (79%) and provided high sensitivity in men (86%) and women (84%) predicting lack of meaningful change in walking speed at 6 months, although specificity was poor to moderate. Conclusions: SDOC cut points for grip strength standardized to weight provided consistent indication of poor walking speed performance post-hip fracture.",
keywords = "Gait speed, Grip strength, Sarcopenia, Weakness",
author = "Orwig, {Denise L.} and Jay Magaziner and Fielding, {Roger A.} and Hao Zhu and Binder, {Ellen F.} and Cawthon, {Peggy M.} and Shalender Bhasin and Rosaly Correa-De-Araujo and Todd Manini and Sheena Patel and Michelle Shardell and Travison, {Thomas G.}",
note = "Funding Information: D.L.O., H.Z., R.C.A., T.M., S.P., M.S., and T.G.T. have no conflicts to report. The following coauthors have received support over the past year. J.M. consulted or served on advisory boards for: American Orthopaedic Association; Novartis; UCB; Pluristem; Viking, Inc. None of these entities provided funding for the current project. R.A.F. received personal fees and/or other support from Axcella Health, Inside Tracker, Biophytis, Astellas, Cytokinetics, Amazentis, Nestle, and Glaxo Smith Kline. E.F.B. received grant support from Astellas Pharma USA and consulting fees from Pfizer. P.M.C. served as a consultant for Bioage, and had grant support from Abbott and Nestle. S.B. received grant support from Abbvie, Transition Therapeutics, Abbott, Metro International Biotechnology, LLC, and Alivegen. These grants and contracts are managed by the Brigham and Women{\textquoteright}s Hospital. He also reports receiving consulting fees from AbbVie and OPKO and holding equity interest in FPT, LLC. Funding Information: The Sarcopenia Definitions and Outcomes Consortium (SDOC) is supported by the National Institute on Aging (NIA, grant number AG51421), the Foundation for the National of Institutes of Health (FNIH, grant numbers CAWT16SARC2 and BHAS16SARC2), and the California Pacific Medical Center Foundation. Additional support was also provided by the National Institute on Aging awards (U01AG05142, R37AG009901, R01AG018668, R01 AG029315, T32AG00262, and P30AG028747). This research was supported in part by the intramural research program at the National Institute on Aging. Dr. Fielding{\textquoteright}s contribution was also supported by the U.S. Department of Agriculture (USDA), under agreement No. 58-1950-4-003. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the USDA. Publisher Copyright: {\textcopyright} The Author(s) 2020.",
year = "2020",
doi = "10.1093/gerona/glaa076",
language = "English",
volume = "75",
pages = "1379--1385",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
number = "7",
}