Application of optical coherence tomography in hereditary, toxic and metabolic optic neuropathies

Jennifer Enright, Gregory Van Stavern

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Hereditary, metabolic and toxic optic neuropathies cause bilateral, central vision loss and therefore can result in severe impairment in visual function. Accurate, early diagnosis is critical, as nutritional and toxic optic neuropathies may be reversible if identified early, and diagnosis of hereditary optic neuropathies can prevent unnecessary invasive workup, provide prognostic information, and allow for effective genetic counseling. Optical coherence tomography (OCT) is a valuable tool that aids in the diagnosis and prognostication of optic neuropathies as it allows for quantification of changes in the retinal ganglion cells (RGCs) and retinal nerve fiber layer (RNFL) over time. We review the characteristic clinical presentations of hereditary, metabolic and toxic optic neuropathies, with an emphasis on OCT findings.

Original languageEnglish
JournalAnnals of Eye Science
Issue numberJune
StatePublished - Jun 2020


  • autosomal dominant optic atrophy (ADOA)
  • ethambutol
  • Leber hereditary optic neuropathy (LHON)
  • optic neuropathy
  • Optical coherence tomography (OCT)


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